Dual natural enzyme-tuned biomineralized nanoflowers for boosting cascade catalytic antibacterial therapy and relieving inflammation

IF 23.2 2区 材料科学 Q1 MATERIALS SCIENCE, COMPOSITES
Hanyu Zhang, Mingdi Zheng, Meng Hao, Xiao Dong, Gemeng Liang, Jinshuo Zou, Yongxin Li, Peitao Xie
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引用次数: 0

Abstract

The development of the non-antibiotic agents that are clinically safe remains a huge challenge in combating bacterial infections. Herein, we report the construction of dual natural enzymes bromelain (Bro) and glucose oxidase (Gox)-based peroxidase-like nanoflowers through copper phosphate biomineralization for synergistic antibacterial/anti-inflammatory therapy. The hybrid nanoflowers firstly exert the Gox activity for catalyzing the oxidation of glucose to produce H2O2, which is subsequently converted into highly reactive ·OH through their peroxidase-like activity. This cascade enzymatic activity endows nanoflowers with excellent antibacterial efficiencies, inhibiting the growth of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) by 99% without the addition of exogenous H2O2, thus greatly reducing toxic side effects. Meanwhile, the nanoflowers downregulate the secretion of pro-inflammatory cytokines and inhibit the inflammatory response through the release of Bro, significantly accelerating the healing of bacteria-infected wounds. Besides, the nanoflowers utilize the biomolecules and endogenous metal species as building blocks, together with a green and simple synthesis method, guaranteeing their biosafety in practical applications. Overall, the unparalleled biocompatibility and robust antibacterial/anti-inflammatory ability make the nanoflowers a highly promising candidate for the treatment of bacterial infections in future clinical applications.

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来源期刊
CiteScore
26.00
自引率
21.40%
发文量
185
期刊介绍: Advanced Composites and Hybrid Materials is a leading international journal that promotes interdisciplinary collaboration among materials scientists, engineers, chemists, biologists, and physicists working on composites, including nanocomposites. Our aim is to facilitate rapid scientific communication in this field. The journal publishes high-quality research on various aspects of composite materials, including materials design, surface and interface science/engineering, manufacturing, structure control, property design, device fabrication, and other applications. We also welcome simulation and modeling studies that are relevant to composites. Additionally, papers focusing on the relationship between fillers and the matrix are of particular interest. Our scope includes polymer, metal, and ceramic matrices, with a special emphasis on reviews and meta-analyses related to materials selection. We cover a wide range of topics, including transport properties, strategies for controlling interfaces and composition distribution, bottom-up assembly of nanocomposites, highly porous and high-density composites, electronic structure design, materials synergisms, and thermoelectric materials. Advanced Composites and Hybrid Materials follows a rigorous single-blind peer-review process to ensure the quality and integrity of the published work.
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