Molecularly imprinted polypyrrole decorated Ti3C2Tx electrochemical sensor for highly selective and sensitive detection of levofloxacin

IF 3.5 3区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

Journal of Materials Science Pub Date : 2024-11-27 DOI:10.1007/s10853-024-10403-2

Divya Hudda, Devendra Kumar

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Abstract

Herein, a rapid and efficient molecular imprinted polymer (MIP) modified Ti₃C₂T_x-based electrochemical sensing platform was developed for levofloxacin detection (LEV). The MIP sensor was designed by depositing the synthesized Ti₃C₂T_x electrophoretically onto the indium tin oxide (ITO) glass surface, followed by electropolymerization of pyrrole as a monomer and LEV as a template molecule. Ti₃C₂T_x significantly enhances the electron transfer rate and offers a larger surface area to increase the number of imprinted sites for precise recognition of LEV. The fabricated sensor (MIP/Ti₃C₂T_x/ITO), under all optimized parameters, demonstrated superior selectivity with a low detection limit (LOD) of 0.76 pM and a linear relationship with LEV concentration ranging (1 pM–100 nM). Additionally, this newly developed sensor exhibited robust stability and sensitivity and successfully detected LEV in actual samples with satisfactory outcomes.

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分子印迹聚吡咯修饰Ti3C2Tx电化学传感器用于左氧氟沙星的高选择性和高灵敏度检测

本文建立了一种快速高效的分子印迹聚合物（MIP）修饰的ti3c2tx电化学传感平台，用于左氧氟沙星（LEV）的检测。将合成的Ti3C2Tx电泳沉积在氧化铟锡（ITO）玻璃表面，然后以吡咯为单体，以LEV为模板分子进行电聚合，设计了MIP传感器。Ti3C2Tx显著提高了电子传递速率，并提供了更大的表面积，以增加印迹位点的数量，从而精确识别LEV。在所有优化参数下，制备的传感器（MIP/Ti3C2Tx/ITO）具有良好的选择性，检出限（LOD）为0.76 pM，与LEV浓度（1 pM - 100 nM）呈线性关系。此外，这种新开发的传感器具有强大的稳定性和灵敏度，并成功地在实际样品中检测到LEV，结果令人满意。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Materials Science 工程技术-材料科学：综合

CiteScore

7.90

自引率

4.40%

发文量

1297

审稿时长

2.4 months

期刊介绍： The Journal of Materials Science publishes reviews, full-length papers, and short Communications recording original research results on, or techniques for studying the relationship between structure, properties, and uses of materials. The subjects are seen from international and interdisciplinary perspectives covering areas including metals, ceramics, glasses, polymers, electrical materials, composite materials, fibers, nanostructured materials, nanocomposites, and biological and biomedical materials. The Journal of Materials Science is now firmly established as the leading source of primary communication for scientists investigating the structure and properties of all engineering materials.