Multifunctional stimuli-responsive self-healing polyvinyl alcohol/tannic acid/thyme-honey/aloe vera hydrogel as promising antibacterial drug delivery platforms: Physicochemical and in vitro biological assays
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引用次数: 0
Abstract
The utilization of hydrogels in biomedical applications has been on the rise due to their capability to create a moist wound environment and composite with a diverse range of organic and mineral compounds. Our objective was to prepare a pH-responsive system with self-healing and excellent antibacterial properties, capable of releasing active agents at the wound site. Polyvinyl alcohol/tannic acid/thyme-honey/aloe vera hydrogels were synthesized through a freeze-thaw method and characterized for structural, chemical, morphological, antibacterial, and cytotoxicity properties. The hydrogels exhibited remarkable mechanical properties, including tensile strength ranging from 2.51 to 331.44 kPa and compression strength from 2.55 to 16.54 kPa, with viscoelastic behavior suitable for various body tissues. They demonstrated an average healing efficiency of 81% within 10 minutes, enduring mechanical stress commonly encountered in wound dressings. The study evaluated their swelling behavior and pH responsiveness, revealing their potential for maintaining a well-hydrated wound environment. The release profiles of tannic acid, thyme-honey, and aloe vera were 82%, 100%, and 88% within 23 days, respectively. The hydrogels demonstrated outstanding antibacterial efficacy, with an average inhibition rate exceeding 98% against both E. coli and S. aureus, and up to 99% with thyme-honey and aloe vera, enhancing cell proliferation capacity. Overall, the samples are non-toxic, antibacterial, and cost-effective, making them suitable for wound healing and drug delivery.
期刊介绍:
Polymer is an interdisciplinary journal dedicated to publishing innovative and significant advances in Polymer Physics, Chemistry and Technology. We welcome submissions on polymer hybrids, nanocomposites, characterisation and self-assembly. Polymer also publishes work on the technological application of polymers in energy and optoelectronics.
The main scope is covered but not limited to the following core areas:
Polymer Materials
Nanocomposites and hybrid nanomaterials
Polymer blends, films, fibres, networks and porous materials
Physical Characterization
Characterisation, modelling and simulation* of molecular and materials properties in bulk, solution, and thin films
Polymer Engineering
Advanced multiscale processing methods
Polymer Synthesis, Modification and Self-assembly
Including designer polymer architectures, mechanisms and kinetics, and supramolecular polymerization
Technological Applications
Polymers for energy generation and storage
Polymer membranes for separation technology
Polymers for opto- and microelectronics.