Associations of body size and morphology with cardiometabolic health in children: the contribution of genetic factors

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity Pub Date : 2024-12-05 DOI:10.1002/oby.24196

Karri Silventoinen, José Maia, Reijo Sund, Élvio R. Gouveia, António Antunes, Gonçalo Marques, Martine Thomis, Aline Jelenkovic, Jaakko Kaprio, Duarte Freitas

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Abstract

Objective

We analyzed how anthropometric measures predict cardiometabolic health and how genetic and environmental factors contribute to these associations.

Methods

Data on 8 indicators of cardiometabolic health, 21 anthropometric measures, and 11 anthropometric indices were available for 216 twin pairs of individuals age 3 to 18 years living in the Autonomous Region of Madeira, Portugal (51% girls). Genetic twin modeling was used to estimate genetic and environmental correlations between the cardiometabolic and anthropometric indicators.

Results

Anthropometric indicators were positively associated with blood pressure and triglycerides and inversely associated with high-density lipoprotein cholesterol. The associations with glucose, low-density lipoprotein cholesterol, total cholesterol, and heart rate were close to zero. BMI and waist circumference showed similar or slightly higher absolute correlations with cardiometabolic health indicators compared with other anthropometric indices. Additive genetic and unique environmental correlations were at the same level as trait correlations.

Conclusions

BMI and waist circumference provide information on cardiometabolic health that is not less accurate than that provided by more comprehensive anthropometric indices. These associations reflect causal associations between obesity and cardiometabolic disorders rather than only shared genetic associations. Measuring obesity is important for monitoring cardiometabolic risks and can be accomplished using simple indicators at the population level.

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儿童体型和形态与心脏代谢健康的关系：遗传因素的影响

目的：我们分析人体测量测量如何预测心脏代谢健康，以及遗传和环境因素对这些关联的影响。方法：对生活在葡萄牙马德拉自治区的216对3 - 18岁的双胞胎（51%为女孩）进行8项心脏代谢健康指标、21项人体测量指标和11项人体测量指标的数据分析。遗传双胞胎模型用于估计心脏代谢和人体测量指标之间的遗传和环境相关性。结果：人体测量指标与血压和甘油三酯呈正相关，与高密度脂蛋白胆固醇呈负相关。与葡萄糖、低密度脂蛋白胆固醇、总胆固醇和心率的关联接近于零。与其他人体测量指标相比，BMI和腰围与心脏代谢健康指标的绝对相关性相似或略高。加性遗传相关和独特环境相关与性状相关处于同一水平。结论：BMI和腰围提供的心脏代谢健康信息的准确性并不低于更全面的人体测量指标。这些关联反映了肥胖和心脏代谢紊乱之间的因果关系，而不仅仅是共同的遗传关联。测量肥胖对于监测心脏代谢风险很重要，可以在人群水平上使用简单的指标来完成。

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来源期刊

Obesity 医学-内分泌学与代谢

CiteScore

11.70

自引率

1.40%

发文量

261

审稿时长

2-4 weeks

期刊介绍： Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.