The role of Mediterranean diet in cancer incidence and mortality in the older adults.

IF 4.1 Q2 GERIATRICS & GERONTOLOGY

npj aging Pub Date : 2024-12-05 DOI:10.1038/s41514-024-00186-w

Giulia Giordano, Luca Mastrantoni, Roberta Terranova, Giuseppe Ferdinando Colloca, Giuseppe Zuccalà, Francesco Landi

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Abstract

The magnitude of benefit of Mediterranean diet in cancer prevention and mortality in older adults is still unclear, therefore we conducted a systematic review and meta-analysis. Outcomes considered were cancer incidence and cancer mortality. In studies evaluating cancer incidence as a time-to-event endpoint and adherence as quantiles, HR was 0.885 (95% CI 0.773-1.013, I² = 44%). Including ORs, exploratory pooled effect size was 0.876 (0.794-0.966, I² = 34%), consistently with results of studies evaluating ORs for adherence as one-point increase (OR 0.744, 0.570-0.972, I² = 90%). No clear benefit was observed on cancer mortality, with pooled HR of 0.935 (0.800-1.093, I² = 0%). Significant differences were observed for ORs according to cancer type but not between medium and high adherence for both outcomes. Certainty of evidence was low. Our findings suggest that MD could play a protective role in cancer incidence in advanced age, but no clear effect on cancer mortality was observed.

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地中海饮食在老年人癌症发病率和死亡率中的作用。

地中海饮食在老年人癌症预防和死亡率方面的益处程度尚不清楚，因此我们进行了系统回顾和荟萃分析。考虑的结果是癌症发病率和癌症死亡率。在以癌症发病率为事件发生时间终点，以依从性为分位数的研究中，HR为0.885 （95% CI 0.773-1.013, I2 = 44%）。包括OR在内，探索性合并效应量为0.876 (0.794-0.966,I2 = 34%)，与评价依从性OR为1点增加的研究结果一致（OR 0.744, 0.570-0.972, I2 = 90%）。在癌症死亡率方面未观察到明显的益处，合并HR为0.935 （0.800-1.093,I2 = 0%）。根据癌症类型，观察到ORs的显著差异，但在两种结果中，中等和高依从性之间没有显著差异。证据的确定性很低。我们的研究结果表明，MD可能对老年癌症发病率有保护作用，但对癌症死亡率没有明显影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

npj aging

CiteScore

8.90

自引率

0.00%

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