Micrognathia and cleft palate as a cause of obstructive sleep apnoea in infants.

IF 2.4 4区医学 Q1 PEDIATRICS

Acta Paediatrica Pub Date : 2024-12-05 DOI:10.1111/apa.17540

Turkka Kirjavainen, Pia Vuola, Janne Suominen, Anne Saarikko

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引用次数: 0

Abstract

Aim: Obstructive sleep apnoea (OSA) is common in Robin sequence (RS). We investigated the significance of micrognathia, cleft palate and sleep positioning on OSA in infants.

Methods: We analysed our 13-year national reference centre polysomnography (PSG) dataset. PSG was performed as daytime recordings (97%) in the supine-, side- and prone sleeping position at the median age of 5 weeks (interquartile range 3-8 weeks).

Results: Our study included 113 infants with RS and cleft palate, 10 infants with RS but intact palate and 32 infants with cleft palate without micrognathia. The degree of OSA in infants with cleft palate without micrognathia was less severe than in infants with RS in terms of obstructive events (median OAHI 4 vs. 32 h^-1, respectively), SpO₂ desaturations (ODI_≥3OAH 0.4 vs. 3 h^-1), transcutaneous pCO₂ levels (TcCO₂P₉₅, 41 vs. 46 mmHg) (p < 0.0001) and work of breathing (p = 0.01). In the RS group, OSA was sleep-position dependent, with fewer obstructive events apparent in the side (18 vs. 24 h^-1, p = 0.005) and prone (39 vs. 27 h^-1, p = 0.003) sleeping positions than when supine.

Conclusions: The degree of OSA in RS infants is more dependent on micrognathia than on cleft palate.

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小颌和腭裂是婴儿阻塞性睡眠呼吸暂停的一个原因。

目的：阻塞性睡眠呼吸暂停（OSA）在罗宾序列（RS）中较为常见。探讨小颌、腭裂和睡眠体位对婴儿睡眠呼吸暂停的影响。方法：我们分析了我们13年的国家参考中心多导睡眠图（PSG）数据集。在平均年龄为5周（四分位数范围为3-8周）时，采用仰卧位、侧卧位和俯卧位进行PSG日间记录（97%）。结果：本研究纳入腭裂合并腭裂患儿113例，腭裂伴完整患儿10例，腭裂伴小颌畸形患儿32例。在阻塞性事件（OAHI中位数分别为4比32 h-1）、SpO2去饱和度（ODI≥3OAH 0.4比3 h-1）、经皮pCO2水平（TcCO2P95, 41比46 mmHg）（p -1, p = 0.005）和俯卧睡位（39比27 h-1， p = 0.003）方面，没有小颌畸形的腭裂婴儿的OSA程度比RS婴儿轻。结论：RS患儿OSA程度对小颌畸形的依赖性大于对腭裂的依赖性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Paediatrica 医学-小儿科

CiteScore

6.50

自引率

5.30%

发文量

384

审稿时长

2-4 weeks

期刊介绍： Acta Paediatrica is a peer-reviewed monthly journal at the forefront of international pediatric research. It covers both clinical and experimental research in all areas of pediatrics including: neonatal medicine developmental medicine adolescent medicine child health and environment psychosomatic pediatrics child health in developing countries