Relating Standardized Automated Perimetry Performed With Stimulus Sizes III and V in Eyes With Field Loss Due to Glaucoma and NAION.

IF 2.6 3区医学 Q2 OPHTHALMOLOGY

Translational Vision Science & Technology Pub Date : 2024-12-02 DOI:10.1167/tvst.13.12.8

David Szanto, Michael Wall, Luke X Chong, Mark J Kupersmith

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引用次数: 0

Abstract

Purpose: Standard automated perimetry (SAP) visual field (VF) results are more repeatable using Goldmann stimulus size V (size V) in eyes with moderate/severe deficits due to glaucoma. There are few reports relating VFs using stimulus size V and III, typically used in the clinic for glaucoma, and none for non-arteritic anterior ischemic optic neuropathy (NAION). We hypothesized that we could compare and relate the VFs with both stimuli for glaucoma and NAION.

Methods: We utilized 1992 same-day pairs of size III and size V SAP VFs using the 24-2 strategy for eyes with glaucoma or NAION. We explored the optimal threshold to censor the raw sensitivities, prior to calculating age-standardized total deviations (TDs). We determined the mean and standard deviation of the differences among all TD pairs. We computed a line of best fit to determine closeness to the line of unity.

Results: The ideal censoring conversion threshold was 21 decibel (dB) for size III and 24 dB for size V. The difference between size V and size III censored (0.0 ± 1.9 dB) and uncensored (0.4 ± 2.6 dB) TD pairings highly correlate with each other (r2 = 0.70, P < 0.001). The line of best fit from these pairings has a slope of 0.92, which is close to that of the line of unity (m = 1).

Conclusions: Censoring plus age correction is a valid method of comparison between size III and size V SAP VFs with moderate to severe VF loss due to optic nerve disorders.

Translational relevance: Size III and size V TDs are comparable in clinical practice.

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用刺激尺寸III和V在青光眼和NAION引起视野丧失的眼睛中进行标准化自动视野测量。

目的：在中度/重度青光眼缺陷的眼睛中，使用Goldmann刺激尺寸V（尺寸V），标准自动视距测量（SAP）视野（VF）结果可重复性更好。很少有关于使用V和III级刺激的VFs的报道，通常用于青光眼的临床治疗，而没有用于非动脉性前缺血性视神经病变（NAION）。我们假设我们可以比较和联系VFs与青光眼和NAION的刺激。方法：我们采用24-2策略对患有青光眼或NAION的眼睛使用1992对当日III和V尺寸的SAP VFs。在计算年龄标准化总偏差（TDs）之前，我们探索了审查原始敏感性的最佳阈值。我们确定了所有TD对之间差异的均值和标准差。我们计算了一条最佳拟合线来确定与统一线的接近程度。结果：III型和V型的理想截音转换阈值分别为21分贝和24分贝。V型和III型截音（0.0±1.9 dB）和未截音（0.4±2.6 dB）的TD配对差异高度相关（r2 = 0.70, P < 0.001）。这些配对的最佳拟合线斜率为0.92，接近统一线（m = 1）。结论：删节加年龄校正是比较III型和V型视神经功能障碍导致的中度至重度视神经功能丧失的SAP视神经功能障碍的有效方法。翻译相关性：III型和V型TDs在临床实践中具有可比性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Translational Vision Science & Technology Engineering-Biomedical Engineering

CiteScore

5.70

自引率

3.30%

发文量

346

审稿时长

25 weeks

期刊介绍： Translational Vision Science & Technology (TVST), an official journal of the Association for Research in Vision and Ophthalmology (ARVO), an international organization whose purpose is to advance research worldwide into understanding the visual system and preventing, treating and curing its disorders, is an online, open access, peer-reviewed journal emphasizing multidisciplinary research that bridges the gap between basic research and clinical care. A highly qualified and diverse group of Associate Editors and Editorial Board Members is led by Editor-in-Chief Marco Zarbin, MD, PhD, FARVO. The journal covers a broad spectrum of work, including but not limited to: Applications of stem cell technology for regenerative medicine, Development of new animal models of human diseases, Tissue bioengineering, Chemical engineering to improve virus-based gene delivery, Nanotechnology for drug delivery, Design and synthesis of artificial extracellular matrices, Development of a true microsurgical operating environment, Refining data analysis algorithms to improve in vivo imaging technology, Results of Phase 1 clinical trials, Reverse translational ("bedside to bench") research. TVST seeks manuscripts from scientists and clinicians with diverse backgrounds ranging from basic chemistry to ophthalmic surgery that will advance or change the way we understand and/or treat vision-threatening diseases. TVST encourages the use of color, multimedia, hyperlinks, program code and other digital enhancements.