Prevalence and Incidence of Type 1 Brugada Pattern: A 30-Year Experience at Mayo Clinic.

IF 6.9 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Mayo Clinic proceedings Pub Date : 2025-01-01 Epub Date: 2024-12-06 DOI:10.1016/j.mayocp.2024.05.028

Pattara Rattanawong, Carolyn Mead-Harvey, Olubadewa A Fatunde, Charles Van Der Walt, Nway Ko Ko, Patrick Hooke, Thanaboon Yinadsawaphan, Narathorn Kulthamrongsri, Win-Kuang Shen, Dan Sorajja

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引用次数: 0

Abstract

Objective: To identify the incidence and prevalence of type 1 Brugada pattern at Mayo Clinic during 30 years.

Methods: We retrospectively reviewed the electronic medical records from 1992 to 2021 at Mayo Clinic Enterprise. Patients with type 1 Brugada pattern electrocardiogram (ECG) were identified by a systematic keyword search. Incidences are calculated by decade. The incidence rate ratios (IRRs) between races were then calculated. Analysis of the association between groups and major arrhythmic event-free survival was conducted.

Results: The study analyzed 5,381,186 ECGs from 2,304,809 patients; 150 patients had at least 1 ECG with a type 1 Brugada pattern (76.0% Brugada syndrome, 62.0% spontaneous, 18.7% fever induced, and 10.7% drug induced). The mean follow-up was 6.6±6.7 years. The incidence (per 100,000 person-years) of type 1 Brugada pattern increased during the past 3 decades (0.505 [95% CI, 0.203 to 1.040], 3.015 [95% CI, 2.272 to 3.925], and 3.916 [95% CI, 3.128 to 4.842]). The incidence in Black patients was approximately 1.5-fold higher compared with non-Hispanic White patients (IRR, 1.492 [95% CI, 0.610 to 3.649]; P=.38). The incidence in Hispanic White patients was 3-fold higher than in non-Hispanic White patients (IRR, 3.021 [95% CI, 1.410 to 6.474]; P=.005). The incidence in Asian patients was 2-fold higher than in Hispanic patients (IRR, 1.894 [95% CI, 0.705 to 5.086]; P=.21). The overall prevalence of the type 1 Brugada pattern between 2010 and 2021 was 10.094 per 100,000. The major arrhythmic events occurred in 8.6%, 7.1%, 12.5%, and 7.7% for spontaneous, fever-induced, drug-induced, and other type 1 Brugada patterns, respectively, during follow-up.

Conclusion: The incidence of type 1 Brugada pattern at Mayo Clinic has increased during 3 decades. The prevalence of type 1 Brugada pattern in the United States is higher than previously reported. Type 1 Brugada pattern in Black and Hispanic populations is more common than previously suspected.

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1型Brugada型的患病率和发病率：梅奥诊所30年的经验。

目的：了解30年来梅奥诊所1型Brugada型的发病率和流行情况。方法：我们回顾性地回顾了梅奥企业诊所1992年至2021年的电子病历。采用系统关键词搜索方法对1型Brugada型心电图（ECG）患者进行识别。发病率是按十年计算的。然后计算不同种族间的发病率比（IRRs）。分析各组与主要无心律失常事件生存率之间的关系。结果：该研究分析了2,304,809例患者的5,381,186张心电图；150例患者至少有1例ECG为1型Brugada型（76.0% Brugada综合征，62.0%自发，18.7%发热诱导，10.7%药物诱导）。平均随访6.6±6.7年。1型Brugada型的发病率（每10万人年）在过去30年中有所增加（0.505 [95% CI, 0.203 ~ 1.040], 3.015 [95% CI, 2.272 ~ 3.925]和3.916 [95% CI, 3.128 ~ 4.842]）。黑人患者的发病率约为非西班牙裔白人患者的1.5倍(IRR, 1.492 [95% CI， 0.610至3.649]；P = 38)。西班牙裔白人患者的发病率是非西班牙裔白人患者的3倍(IRR, 3.021 [95% CI, 1.410 ~ 6.474]；P = .005)。亚洲患者的发病率是西班牙裔患者的2倍(IRR, 1.894 [95% CI, 0.705 ~ 5.086]；P = . 21)。2010年至2021年间，1型布鲁加达型的总体患病率为10.094 / 10万。随访期间，自发性、发热性、药物性和其他1型Brugada模式的主要心律失常发生率分别为8.6%、7.1%、12.5%和7.7%。结论：近30年来，梅奥诊所1型Brugada型的发病率呈上升趋势。1型Brugada型在美国的流行率高于以前的报道。1型Brugada型在黑人和西班牙裔人群中比先前怀疑的更为常见。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mayo Clinic proceedings 医学-医学：内科

CiteScore

16.80

自引率

1.10%

发文量

383

审稿时长

37 days

期刊介绍： Mayo Clinic Proceedings is a premier peer-reviewed clinical journal in general medicine. Sponsored by Mayo Clinic, it is one of the most widely read and highly cited scientific publications for physicians. Since 1926, Mayo Clinic Proceedings has continuously published articles that focus on clinical medicine and support the professional and educational needs of its readers. The journal welcomes submissions from authors worldwide and includes Nobel-prize-winning research in its content. With an Impact Factor of 8.9, Mayo Clinic Proceedings is ranked #20 out of 167 journals in the Medicine, General and Internal category, placing it in the top 12% of these journals. It invites manuscripts on clinical and laboratory medicine, health care policy and economics, medical education and ethics, and related topics.