[Retracted] Hypoxia‑induced overexpression of DEC1 is regulated by HIF‑1α in hepatocellular carcinoma.

IF 3.8 3区 医学 Q2 ONCOLOGY
Oncology reports Pub Date : 2025-02-01 Epub Date: 2024-12-05 DOI:10.3892/or.2024.8850
Wanshan Ma, Xiaohong Shi, Sumei Lu, Linlin Wu, Yunshan Wang
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引用次数: 0

Abstract

Further to the publication of the above paper, a concerned reader drew to our attention that, in Figs. 1A and 4A, the same loading controls for the RT‑PCR experiments portrayed had apparently been incorporated into these figures, even though the experimental results (i.e., for the DEC1 bands) were otherwise different. In addition, the control GAPDH bands featured in the western blots in Figs. 3A and 3B for the SMMC‑7721 and BRL‑7402 cell lines respectively were strikingly similar, albeit the bands appeared to have been vertically flipped in Fig. 3A relative to Fig. 3B, and possibly stretched. The Editorial Office subsequently investigated this matter, and were able to confirm the concerns of the reader. After having considered the various issues that have been brought to light with this paper, in spite of a request from the authors that a Corrigendum be published, the Editor of Oncology Reports has determined that the article should be retracted on account of a lack of overall confidence in the presented data. The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a reply. The Editor apologizes to the readership for any inconvenience caused. [Oncology Reports 30: 2957‑2962, 2013; DOI: 10.3892/or.2013.2774].

在肝细胞癌中,缺氧诱导的DEC1过表达受HIF - 1α调控。
在上述论文发表后,一位关心的读者提请我们注意,在图1A和4A中,所描绘的RT - PCR实验的相同负载控制显然已纳入这些图中,尽管实验结果(即DEC1波段)在其他方面有所不同。此外,SMMC - 7721和BRL - 7402细胞系的对照GAPDH条带在图3A和3B中分别出现了惊人的相似,尽管这些条带在图3A中相对于图3B似乎已经垂直翻转,并且可能被拉伸。编辑部随后对此事进行了调查,并证实了读者的担忧。在考虑了这篇论文所揭示的各种问题之后,尽管作者要求发表一份勘误表,但《肿瘤学报告》的编辑决定,由于对所提供的数据缺乏总体信心,这篇文章应该被撤回。作者被要求对这些担忧作出解释,但编辑部没有收到答复。对于由此给读者带来的不便,本刊编辑深表歉意。肿瘤学报告30:2957‑2962,2013;DOI: 10.3892 / or.2013.2774]。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Oncology reports
Oncology reports 医学-肿瘤学
CiteScore
8.50
自引率
2.40%
发文量
187
审稿时长
3 months
期刊介绍: Oncology Reports is a monthly, peer-reviewed journal devoted to the publication of high quality original studies and reviews concerning a broad and comprehensive view of fundamental and applied research in oncology, focusing on carcinogenesis, metastasis and epidemiology.
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