Alterations in regional homogeneity in schizophrenia patients comorbid with metabolic syndrome treated with risperidone or clozapine

IF 3.7 2区 医学 Q1 PSYCHIATRY
Xinyue Chen , Xinyan Wu , Wenjing Zhang , Kaike Liao , Rui Yu , Su Lui , Nian Liu
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Abstract

The neuroimaging mechanisms that arise in patients with schizophrenia and comorbid metabolic syndrome (MetS) remain poorly understood. This study was devised to examine potential alterations in regional homogeneity (ReHo) that arise in schizophrenia patients with comorbid MetS undergoing risperidone or clozapine treatment. In total, 43 schizophrenia patients undergoing risperidone or clozapine treatment were enrolled in this study, of whom 20 had comorbid MetS (SZ-MetS) while 23 did not (SZ-nMetS). In addition, 28 sex- and age-matched healthy controls (HCs) were analyzed. Analyses of covariance (ANCOVA) were used to compare ReHo in this study, utilizing age, sex, and years of education as covariates, with subsequent post hoc testing. Correlations between brain regions showing differences between groups of patients with schizophrenia and MetS-related indicators were also assessed. Relative to HCs, patients in both the SZ-MetS and SZ-nMetS groups exhibited reductions in ReHo in the right postcentral gyrus, left superior parietal gyrus, and left middle occipital gyrus. A decrease in ReHo was also evident in the left calcarine fissure and surrounding cortex and the right angular gyrus of patients in the SZ-MetS group, while the SZ-nMetS group exhibited reductions in ReHo in the left superior occipital gyrus and the right precuneus, together with an increase in ReHo in the right inferior orbitofrontal gyrus. Compared to the SZ-nMetS group, the SZ-MetS group exhibited a reduction in ReHo in the right inferior orbitofrontal gyrus. The ReHo of the right inferior orbitofrontal gyrus was significantly negatively correlated with BMI, waist circumference, and hip circumference in the SZ-MetS and SZ-nMetS groups. A reduction in ReHo in the right inferior orbitofrontal gyrus may thus be related to MetS in schizophrenia patients undergoing treatment. The findings may provide an imaging basis for brain alterations in patients with schizophrenia combined with MetS and provide a new insight into the neuroimaging mechanisms associated with MetS in patients with schizophrenia.
利培酮或氯氮平治疗伴有代谢综合征的精神分裂症患者的区域同质性改变
出现在精神分裂症和共病代谢综合征(MetS)患者的神经影像学机制仍然知之甚少。本研究旨在检查在接受利培酮或氯氮平治疗的合并met的精神分裂症患者中出现的区域均匀性(ReHo)的潜在改变。本研究共纳入43例接受利培酮或氯氮平治疗的精神分裂症患者,其中20例合并合并MetS (SZ-MetS), 23例未合并(SZ-nMetS)。此外,还分析了28名性别和年龄匹配的健康对照(hc)。本研究采用协方差分析(ANCOVA),以年龄、性别和受教育年限作为协变量,与随后的事后检验比较ReHo。还评估了显示精神分裂症患者组之间差异的脑区域和mets相关指标之间的相关性。与hc相比,SZ-MetS组和SZ-nMetS组的患者在右侧中央后回、左侧顶叶上回和左侧枕中回的ReHo均有所减少。SZ-MetS组患者左侧钙骨裂及其周围皮层和右侧角回的ReHo也明显降低,而SZ-nMetS组患者左侧枕上回和右侧楔前叶的ReHo降低,右侧眶额下回的ReHo升高。与SZ-nMetS组相比,SZ-MetS组右下眶额回的ReHo减少。SZ-MetS组和SZ-nMetS组右下眶额回ReHo与BMI、腰围、臀围呈显著负相关。因此,在接受治疗的精神分裂症患者中,右下眶额回ReHo的减少可能与MetS有关。该发现可能为精神分裂症合并MetS患者的脑改变提供影像学基础,并为精神分裂症患者与MetS相关的神经影像学机制提供新的见解。
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来源期刊
Journal of psychiatric research
Journal of psychiatric research 医学-精神病学
CiteScore
7.30
自引率
2.10%
发文量
622
审稿时长
130 days
期刊介绍: Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;
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