Mycobacterium leprae infection with rash misdiagnosed as a flare-up of systemic lupus erythematosus: a case report

IF 2.1 4区医学 Q3 INFECTIOUS DISEASES

Diagnostic microbiology and infectious disease Pub Date : 2024-11-27 DOI:10.1016/j.diagmicrobio.2024.116622

Yihan Zhao , Shijie Huang , Tong Wu

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引用次数: 0

Abstract

Background: Leprosy (Hansen's disease) is a curable, chronic contact infectious disease caused by Mycobacterium leprae. It mainly affects human skin and nerves and can cause progressive and permanent damage to the skin, nerves, limbs, eyes and is of great concern to the medical community.

Case presentation: A 35-year-old Han Chinese female patient presented to our hospital with 11 years of recurrent erythema and pain in the limbs and face, which was aggravated by fever for 6 days. The patient had an 11-year history of systemic lupus erythematosus (SLE). Initially, lupus was considered to be active and was subsequently treated with methylprednisolone; however, the rash was not controlled. By completing pathohistological examination, immunohistochemistry, and antacid staining, according to the Ridley-Jopling classification of leprosy, confirmed a diagnosis of lepromatous leprosy.

Conclusions: This report will help increase awareness of leprosy in patients with immune disorders to reduce the rate of misdiagnosis and mistreatment.

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麻风分枝杆菌感染伴皮疹误诊为系统性红斑狼疮突发：1例报告。

背景：麻风（汉森病）是由麻风分枝杆菌引起的一种可治愈的慢性接触性传染病。它主要影响人体皮肤和神经，可对皮肤、神经、四肢、眼睛造成进行性和永久性损伤，引起医学界的高度关注。病例介绍：35岁汉族女性患者，11年复发性红斑，四肢及面部疼痛，发热加重6天。患者有系统性红斑狼疮（SLE）病史11年。最初，狼疮被认为是活跃的，随后用甲基强的松龙治疗；然而，皮疹并没有得到控制。通过完成病理组织学检查、免疫组织化学和抗酸染色，根据麻风的Ridley-Jopling分类，确诊为麻风性麻风。结论：本报告将有助于提高免疫障碍患者对麻风病的认识，降低误诊和误治率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diagnostic microbiology and infectious disease 医学-传染病学

CiteScore

5.30

自引率

3.40%

发文量

149

审稿时长

56 days

期刊介绍： Diagnostic Microbiology and Infectious Disease keeps you informed of the latest developments in clinical microbiology and the diagnosis and treatment of infectious diseases. Packed with rigorously peer-reviewed articles and studies in bacteriology, immunology, immunoserology, infectious diseases, mycology, parasitology, and virology, the journal examines new procedures, unusual cases, controversial issues, and important new literature. Diagnostic Microbiology and Infectious Disease distinguished independent editorial board, consisting of experts from many medical specialties, ensures you extensive and authoritative coverage.