Correlation of Porphyromonas gingivalis with esophageal squamous cell carcinoma: a systematic review.

IF 3.1 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Investigations Pub Date : 2024-12-06 DOI:10.1007/s00784-024-06094-3

Avideh Maboudi, Kaveh Hajifathalian, Zeynab Negahban, Anahita Lotfizadeh, Mahmood Moosazadeh, Abbas Mesgarani, Tahereh Molania

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引用次数: 0

Abstract

Objectives: This study aimed to assess the correlation of Porphyromonas gingivalis (P. gingivalis) with esophageal squamous cell carcinoma (ESCC).

Materials and methods: This systematic review evaluated case-control, cohort, and cross-sectional studies published between 1990 and 2024 that compared ESCC patients and healthy controls regarding the presence of P. gingivalis, risk of ESCC development, overall survival rate and prognosis of ESCC, lymph node metastasis, clinical stage of the disease, cancer cell proliferation and migration, efficacy of chemotherapy, invasion depth, and cell differentiation. Searching process was conducted in Web of Science, Scopus, PubMed, and Cochrane Library. The quality of included studies was assessed by the Newcastle Ottawa scale (NOS).

Results: Of 270 articles, 11 underwent a systematic review with NOS scores ranging from 7 to 9. 5 studies found a correlation between P.gingivalis and overall survival rate of ESCC patients (P < 0.05). 5 studies found a significant correlation between P.gingivalis count and the risk of ESCC development (P < 0.05). 2 studies showed a significant correlation between lymph node metastasis and 3 studies showed a significant correlation between clinical TNM stage and P.gingivalis (P < 0.05).

Conclusions: High P. gingivalis count increases the risk of development of ESCC, lymph node metastasis, progression to stages 3 and 4, proliferation and migration of cancer cells, and depth of invasion, decreases the overall survival rate and prognosis of the disease, and efficacy of chemotherapy, and results in poorer differentiation of cells.

Clinical relevance: According to our findings, dental clinicians and patients should be informed about the significance of oral hygiene and its relationship with ESCC to prevent future life-threatening diseases.

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来源期刊

Clinical Oral Investigations 医学-牙科与口腔外科

CiteScore

6.30

自引率

5.90%

发文量

484

审稿时长

3 months

期刊介绍： The journal Clinical Oral Investigations is a multidisciplinary, international forum for publication of research from all fields of oral medicine. The journal publishes original scientific articles and invited reviews which provide up-to-date results of basic and clinical studies in oral and maxillofacial science and medicine. The aim is to clarify the relevance of new results to modern practice, for an international readership. Coverage includes maxillofacial and oral surgery, prosthetics and restorative dentistry, operative dentistry, endodontics, periodontology, orthodontics, dental materials science, clinical trials, epidemiology, pedodontics, oral implant, preventive dentistiry, oral pathology, oral basic sciences and more.