Ferroptosis in Cardiovascular Diseases and Ferroptosis-Related Intervention Approaches.

IF 3.1 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Drugs and Therapy Pub Date : 2024-12-06 DOI:10.1007/s10557-024-07642-5

Xianpeng Zhou, Hao Wang, Biao Yan, Xinwen Nie, Qingjie Chen, Xiaosong Yang, Min Lei, Xiying Guo, Changhan Ouyang, Zhanhong Ren

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引用次数: 0

Abstract

Objective: Cardiovascular diseases (CVDs) are major public health problems that threaten the lives and health of individuals. The article has reviewed recent progresses about ferroptosis and ferroptosis-related intervention approaches for the treatment of CVDs and provided more references and strategies for targeting ferroptosis to prevent and treat CVDs.

Methods: A comprehensive review was conducted using the literature researches.

Results and discussion: Many ferroptosis-targeted compounds and ferroptosis-related genes may be prospective targets for treating CVDs and our review provides a solid foundation for further studies about the detailed pathological mechanisms of CVDs.

Conclusion: There are challenges and limitations about the translation of ferroptosis-targeted potential therapies from experimental research to clinical practice. It warrants further exploration to pursure safer and more effective ferroptosis-targeted thereapeutic approaches for CVDs.

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心血管疾病中的铁下垂及相关干预方法。

目的：心血管疾病（cvd）是威胁人类生命健康的重大公共卫生问题。本文综述了近年来关于铁中毒及与铁中毒相关的心血管疾病干预方法的研究进展，为针对铁中毒预防和治疗心血管疾病提供更多参考和策略。方法：综合文献资料进行综述。结果与讨论：许多铁中毒靶向化合物和铁中毒相关基因可能是治疗cvd的潜在靶点，为进一步研究cvd的详细病理机制提供了坚实的基础。结论：以铁中毒为目标的潜在治疗方法从实验研究到临床实践的转化存在挑战和局限性。值得进一步探索更安全、更有效的针对心血管疾病的铁中毒治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiovascular Drugs and Therapy 医学-心血管系统

CiteScore

8.30

自引率

0.00%

发文量

110

审稿时长

4.5 months

期刊介绍： Designed to objectively cover the process of bench to bedside development of cardiovascular drug, device and cell therapy, and to bring you the information you need most in a timely and useful format, Cardiovascular Drugs and Therapy takes a fresh and energetic look at advances in this dynamic field. Homing in on the most exciting work being done on new therapeutic agents, Cardiovascular Drugs and Therapy focusses on developments in atherosclerosis, hyperlipidemia, diabetes, ischemic syndromes and arrhythmias. The Journal is an authoritative source of current and relevant information that is indispensable for basic and clinical investigators aiming for novel, breakthrough research as well as for cardiologists seeking to best serve their patients. Providing you with a single, concise reference tool acknowledged to be among the finest in the world, Cardiovascular Drugs and Therapy is listed in Web of Science and PubMed/Medline among other abstracting and indexing services. The regular articles and frequent special topical issues equip you with an up-to-date source defined by the need for accurate information on an ever-evolving field. Cardiovascular Drugs and Therapy is a careful and accurate guide through the maze of new products and therapies which furnishes you with the details on cardiovascular pharmacology that you will refer to time and time again.