Fanconi syndrome with acute proximal tubular injury induced by a dietary supplement containing beni-koji: a case series report.

IF 2.2 4区 医学 Q2 UROLOGY & NEPHROLOGY
Masato Habuka, Michihiro Hosojima, Yusuke Yata, Kenshiro Kurumada, Moeri Yamagiwa, Masataka Yonezawa, Masanori Sudo, Hideyuki Kabasawa, Asa Ogawa, Hitomi Hama, Yumi Ito, Naofumi Imai, Suguru Yamamoto, Akihiko Saito, Shin Goto
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Abstract

Background: Fanconi syndrome is a disorder of the proximal tubule that leads to malabsorption of various electrolytes and substances and is a common consequence of drug-induced nephrotoxicity. However, cases of dietary supplement-induced Fanconi syndrome are rare, and detailed reports on the evaluation of renal histology in patients with this syndrome are lacking.

Case presentation: We present two cases of dietary supplement-induced Fanconi syndrome that was confirmed by kidney biopsy. Based on their medical history and laboratory and histological findings, both cases were diagnosed as acute proximal tubular injury caused by ingestion of a lipid-lowering dietary supplement containing beni-koji leading to Fanconi syndrome. After discontinuation of the dietary supplement and correction of dehydration and electrolyte imbalance, renal function completely recovered in one case but progressed to chronic kidney disease in the other.

Conclusions: Clinicians should consider dietary supplement-induced Fanconi syndrome as a differential diagnosis in patients who become ill while taking a dietary supplement. Kidney biopsy is useful for diagnosing acute tubular injury with Fanconi syndrome and investigating its pathogenesis. Patients who have developed dietary supplement-induced Fanconi syndrome require long-term monitoring to detect and prevent progression to chronic kidney disease.

范可尼综合征与急性近端肾小管损伤由含有贝曲的膳食补充剂:一个病例系列报告。
背景:范可尼综合征是一种导致多种电解质和物质吸收不良的近端小管疾病,是药物性肾毒性的常见后果。然而,膳食补充剂引起的Fanconi综合征的病例很少,并且缺乏对该综合征患者肾脏组织学评估的详细报道。病例介绍:我们报告两例膳食补充剂引起的范可尼综合征,经肾活检证实。根据他们的病史、实验室和组织学检查结果,这两例都被诊断为急性近端小管损伤,这是由于摄入含有贝尼曲的降脂膳食补充剂导致的范可尼综合征。停用膳食补充剂并纠正脱水和电解质失衡后,1例肾功能完全恢复,另1例发展为慢性肾病。结论:临床医生应考虑膳食补充剂引起的范可尼综合征作为鉴别诊断的患者患病时服用膳食补充剂。肾活检对诊断范可尼综合征急性肾小管损伤及探讨其发病机制有重要意义。患有膳食补充剂诱导的范可尼综合征的患者需要长期监测,以发现和预防进展为慢性肾脏疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMC Nephrology
BMC Nephrology UROLOGY & NEPHROLOGY-
CiteScore
4.30
自引率
0.00%
发文量
375
审稿时长
3-8 weeks
期刊介绍: BMC Nephrology is an open access journal publishing original peer-reviewed research articles in all aspects of the prevention, diagnosis and management of kidney and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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