Epidemiological, clinical and mortality trends in people with HIV over 60 years in the PISCIS population-based cohort from Catalonia and Balearic Islands.

IF 3.4 2区 医学 Q3 IMMUNOLOGY
AIDS Pub Date : 2025-01-01 Epub Date: 2024-09-19 DOI:10.1097/QAD.0000000000004018
Andreu Bruguera, Daniel K Nomah, Sergio Moreno-Fornés, Esteban Martinez, Eugènia Negredo, Juan Tiraboschi, Jordi Navarro, Pere Domingo, Francisco Fanjul, Aroa Villoslada, Joaquim Peraire, Angeles Jaen, José M Miró, Jordi Casabona, Juliana Reyes-Urueña
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引用次数: 0

Abstract

Objective: With HIV now a chronic condition and an aging population, understanding the evolving profiles of older people with HIV (PWH) is crucial. In this longitudinal study, we examined changes in epidemiological and mortality trends among aging PWH aged 60 and above from 1998 to 2021.

Design: The study constructed four retrospective cohorts based on our calendar periods, reflecting the changing epidemiology of HIV - 1998-2003, 2004-2008, 2009-2014, and 2015-2021. Each calendar period included patients on follow-up that turned 60 during that period in PISCIS, the Populational HIV Cohort from Catalonia and Balearic Islands.

Methods: Sociodemographic and clinical characteristics were analyzed and compared between periods, and 5-year mortality-associated factors were assessed.

Results: Results indicate the proportion of those infected through intravenous drug use in older PWH has increased (4.7% in 1998-2003 vs. 24.7% in 2015-2021), as well as those born outside Spain (7.5% vs. 21.8%), alongside a lesser percentage of late HIV diagnoses (59.9% vs. 46.8%), reflecting a change in older PWH epidemiological profile. The presence of ≥3 comorbidities emerged as a significant predictor of 5-year mortality in the latest cohort, while CD4+ cell count of <200 cells/μl at the age of 60 lost significance [1998-2008: hazard ratio (HR): 3.19 (confidence interval, CI: 1.18-8.63) - 2015-2021: HR:1.38 (CI: 0.74-2.59)], underscoring the transition to the chronic disease era of the HIV pandemic.

Conclusion: Despite advanced treatment strategies have improved HIV health indicators, new challenges have emerged among the older PWH. Tailored interventions addressing the unique difficulties faced by this population are essential to optimize HIV care outcomes.

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来源期刊
AIDS
AIDS 医学-病毒学
CiteScore
5.90
自引率
5.30%
发文量
478
审稿时长
3 months
期刊介绍: ​​​​​​​​​​​​​​​​​Publishing the very latest ground breaking research on HIV and AIDS. Read by all the top clinicians and researchers, AIDS has the highest impact of all AIDS-related journals. With 18 issues per year, AIDS guarantees the authoritative presentation of significant advances. The Editors, themselves noted international experts who know the demands of your work, are committed to making AIDS the most distinguished and innovative journal in the field. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.
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