Comparison of Clinical and Electrophysiologic Characteristics of Peripheral Neuropathy in Progressive Supranuclear Palsy and Parkinson's Disease: An Observational Study.

IF 1.9 4区 医学 Q3 CLINICAL NEUROLOGY
Annals of Indian Academy of Neurology Pub Date : 2025-01-01 Epub Date: 2024-12-05 DOI:10.4103/aian.aian_512_24
Yumkham M Devi, Mritunjai Kumar, Ashutosh Tiwari, Minakshi Dhar, Sweety Kumari, Niraj Kumar
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引用次数: 0

Abstract

Background and objectives: Although widely described in Parkinson's disease (PD), peripheral neuropathy (PNP) is scarcely reported in progressive supranuclear palsy (PSP). We aimed to compare the frequency, clinical and electrophysiologic characteristics of PNP in PSP and PD patients.

Methods: This cross-sectional study included 23 PSP and 93 PD patients. Demographic data, Movement Disorders Society-Unified Parkinson's Disease Rating Scale-III (MDS-UPDRS-III), Hoehn-Yahr staging, Toronto Clinical Neuropathy Score, nerve conduction study (NCS), and sympathetic skin response (SSR) were recorded. Diagnosing isolated large fiber neuropathy required abnormal NCS. Isolated small fiber neuropathy required clinical findings of pinprick and thermal sensory loss and/or allodynia and/or hyperalgesia with/without impaired SSR, along with normal NCS.

Results: PNP was commoner in PSP than PD (65.2% vs. 50.5%, P = 0.21). While a comparable proportion in both groups had clinical neuropathy, NCS abnormalities predominated in PSP (65.2% vs. 39.8%, P = 0.03). All patients had distal symmetrical axonal polyneuropathy. A significantly higher proportion of PSP patients had large fiber involvement (65.21% vs. 39.78%, χ 2 = 4.82; P = 0.03) and mixed fiber PNP (60.9% vs. 33.3%, P = 0.01). PSP patients with neuropathy had a significantly shorter disease duration [median (interquartile range {IQR} = 2 (2-3) years vs. 6 (3-9) years, P < 0.001], higher MDS-UPDRS-III score [median (IQR) = 47 (36-54) vs. 34 (28-49), P = 0.049], higher Hoehn-Yahr stage [median (IQR) = 4 (2-5) vs. 3 (1-5), P < 0.001], and shorter duration of levodopa use [median (IQR) = 2 (1-2) years vs. 3.5 (2-5) years, P = 0.006]. NCS parameters were comparable between PSP and PD patients with neuropathy. While PNP in PSP was not associated with any of the clinical variables, a longer disease duration was independently associated with PNP in PD.

Conclusions: PNP affected two-thirds of PSP patients and was more prevalent than PD. Both groups had distal symmetrical axonal polyneuropathy, with mixed fiber PNP predominating in PSP. A longer disease duration in PD was associated with PNP.

进行性核上性麻痹和帕金森病周围神经病变的临床和电生理特征比较:一项观察性研究。
背景和目的:虽然周围神经病变(PNP)在帕金森病(PD)中被广泛报道,但在进行性核上性麻痹(PSP)中几乎没有报道。我们的目的是比较PSP和PD患者PNP的频率、临床和电生理特征。方法:对23例PSP患者和93例PD患者进行横断面研究。记录人口统计数据、运动障碍学会统一帕金森病评定量表- iii (MDS-UPDRS-III)、Hoehn-Yahr分期、多伦多临床神经病评分、神经传导研究(NCS)和交感皮肤反应(SSR)。诊断孤立的大纤维神经病需要异常的NCS。孤立的小纤维神经病变需要有针刺和热感觉丧失和/或异常性疼痛和/或痛觉过敏的临床表现,伴有/不伴有SSR受损,同时伴有正常的NCS。结果:PNP在PSP中较PD常见(65.2% vs. 50.5%, P = 0.21)。两组患者均有相当比例的临床神经病变,但PSP患者以NCS异常为主(65.2% vs. 39.8%, P = 0.03)。所有患者均有远端对称轴突多发性神经病。PSP患者纤维受累较大的比例较高(65.21% vs. 39.78%, χ2 = 4.82;P = 0.03)和混合纤维PNP (60.9% vs. 33.3%, P = 0.01)。伴有神经病变的PSP患者病程明显缩短[中位数(四分位数间距{IQR} = 2(2-3)年比6(3-9)年,P < 0.001], MDS-UPDRS-III评分较高[中位数(IQR) = 47(36-54)比34 (28-49),P = 0.049], Hoehn-Yahr分期较高[中位数(IQR) = 4(2-5)比3 (1-5),P < 0.001],左旋多巴使用时间较短[中位数(IQR) = 2(1-2)年比3.5(2-5)年,P = 0.006]。神经病变PSP和PD患者的NCS参数具有可比性。PSP患者的PNP与任何临床变量无关,而PD患者病程较长与PNP独立相关。结论:PNP影响了三分之二的PSP患者,比PD更普遍。两组均有远端对称轴突多神经病变,以混合纤维PNP为主。PD患者病程越长与PNP相关。
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来源期刊
Annals of Indian Academy of Neurology
Annals of Indian Academy of Neurology Nervous System Diseases-
CiteScore
2.20
自引率
11.80%
发文量
293
审稿时长
29 weeks
期刊介绍: The journal has a clinical foundation and has been utilized most by clinical neurologists for improving the practice of neurology. While the focus is on neurology in India, the journal publishes manuscripts of high value from all parts of the world. Journal publishes reviews of various types, original articles, short communications, interesting images and case reports. The journal respects the scientific submission of its authors and believes in following an expeditious double-blind peer review process and endeavors to complete the review process within scheduled time frame. A significant effort from the author and the journal perhaps enables to strike an equilibrium to meet the professional expectations of the peers in the world of scientific publication. AIAN believes in safeguarding the privacy rights of human subjects. In order to comply with it, the journal instructs all authors when uploading the manuscript to also add the ethical clearance (human/animals)/ informed consent of subject in the manuscript. This applies to the study/case report that involves animal/human subjects/human specimens e.g. extracted tooth part/soft tissue for biopsy/in vitro analysis.
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