Effect of short and long-term cadmium exposure on behaviour and cardiac function in Drosophila.

IF 7.6 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Jessica J. Wellings, Jamie M. Thorpe, Karen Yendole, Yutaka Matsubayashi, Paul S. Hartley
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引用次数: 0

Abstract

Cadmium is a non-essential heavy metal and environmental pollutant that causes a range of pathologies across different species. In humans, cadmium exposure has recently been directly linked to heart disease. Understanding how long-term cadmium exposure affects cardiac physiology is therefore important. In this work we employed a tractable Drosophila melanogaster model to study the effects of cadmium exposure on behaviour, lifespan and cardiac physiology. Dietary experiments established that cadmium at 10 μM and 100 μM was tolerated for several weeks, whereas doses in the mM range caused lethality within days. It was estimated that 10 μM dietary exposure represented an approximately 60-fold excess of the maximum exposure recommended for humans. Although 10 μM cadmium had no impact on lifespan compared to the control diet, it did cause significant daytime hyperactivity. Direct exposure of the heart to cadmium caused reversible cardiac arrest and disrupted calcium signalling. Compared to controls, 10 μM dietary cadmium had no impact on the rate of cardiac ageing over a six-week period. The higher dose of 100 μM shortened the flies’ lifespan but it slowed the rate of cardiac ageing. The findings indicate that Drosophila can be used to model the direct effects of cadmium on cardiomyocyte function and also demonstrate the existence of cardioprotective pathways triggered by dietary cadmium exposure. The data also indicate that cadmium at doses that do not affect lifespan or heart function, do cause daytime hyperactivity. Identifying and the cardioprotective mechanisms and understanding the hyperactivity phenotype in Drosophila may yield important findings of applied relevance to insects in general, as well as humans exposed to cadmium.

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来源期刊
Environmental Pollution
Environmental Pollution 环境科学-环境科学
CiteScore
16.00
自引率
6.70%
发文量
2082
审稿时长
2.9 months
期刊介绍: Environmental Pollution is an international peer-reviewed journal that publishes high-quality research papers and review articles covering all aspects of environmental pollution and its impacts on ecosystems and human health. Subject areas include, but are not limited to: • Sources and occurrences of pollutants that are clearly defined and measured in environmental compartments, food and food-related items, and human bodies; • Interlinks between contaminant exposure and biological, ecological, and human health effects, including those of climate change; • Contaminants of emerging concerns (including but not limited to antibiotic resistant microorganisms or genes, microplastics/nanoplastics, electronic wastes, light, and noise) and/or their biological, ecological, or human health effects; • Laboratory and field studies on the remediation/mitigation of environmental pollution via new techniques and with clear links to biological, ecological, or human health effects; • Modeling of pollution processes, patterns, or trends that is of clear environmental and/or human health interest; • New techniques that measure and examine environmental occurrences, transport, behavior, and effects of pollutants within the environment or the laboratory, provided that they can be clearly used to address problems within regional or global environmental compartments.
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