Toxic effects of exposure to Polymethyl methacrylate and polyvinyl chloride microplastics in Pacific oysters (Crassostrea gigas)

IF 7.6 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Chunmei Gao, Zhuolong Wu, Baogui Liang, Jikun Lu, Guanghui Fu, Miaomiao Sun, Wenwen Yu, Shuo Zhang, Shike Gao
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引用次数: 0

Abstract

Increasing attention has been directed toward the toxic effects of microplastics (MP) on marine mollusks in recent years. To evaluate these effects, Pacific oysters (Crassostrea gigas) were acclimated and cultured in a 140-liter container, where two types of MP, polymethyl methacrylate (PMMA) and polyvinyl chloride (PVC), were introduced into their feed. MP concentrations in the water were maintained at 300 μg/L, 600 μg/L, and 900 μg/L to assess oxidative stress, DNA damage, and metabolic disorders in these organisms. Significant alterations in antioxidant enzyme activities were detected in C. gigas exposed to these pollutants. After 30 days of exposure to high concentrations of PMMA, superoxide dismutase (SOD) activity in the adductor muscle was reduced by 59% compared to the control group, while catalase (CAT) activity increased by 67%. DNA damage assessments revealed that NF-κB expression levels reached a maximum value of 2.46 in the high-concentration PMMA group after 30 days, the highest among all experimental groups. Additionally, metabolic pathway alterations in the hepatopancreas of C. gigas were observed, including reduced expression levels of uridine and methylmalonic acid (MMA), alongside significantly elevated expression levels of glutamic acid and asparagine. This study offers essential toxicological data for understanding and quantifying the impacts of PMMA and PVC MP on marine mollusks.

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来源期刊
Environmental Pollution
Environmental Pollution 环境科学-环境科学
CiteScore
16.00
自引率
6.70%
发文量
2082
审稿时长
2.9 months
期刊介绍: Environmental Pollution is an international peer-reviewed journal that publishes high-quality research papers and review articles covering all aspects of environmental pollution and its impacts on ecosystems and human health. Subject areas include, but are not limited to: • Sources and occurrences of pollutants that are clearly defined and measured in environmental compartments, food and food-related items, and human bodies; • Interlinks between contaminant exposure and biological, ecological, and human health effects, including those of climate change; • Contaminants of emerging concerns (including but not limited to antibiotic resistant microorganisms or genes, microplastics/nanoplastics, electronic wastes, light, and noise) and/or their biological, ecological, or human health effects; • Laboratory and field studies on the remediation/mitigation of environmental pollution via new techniques and with clear links to biological, ecological, or human health effects; • Modeling of pollution processes, patterns, or trends that is of clear environmental and/or human health interest; • New techniques that measure and examine environmental occurrences, transport, behavior, and effects of pollutants within the environment or the laboratory, provided that they can be clearly used to address problems within regional or global environmental compartments.
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