Regioselective Cobalt‐Catalyzed Protoboration of Alkynes

IF 4.4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2024-12-06 DOI:10.1002/adsc.202401334

Ho Seong Hwang, Eun Jin Cho

引用次数: 0

Abstract

A regioselective cobalt‐catalyzed protoboration of alkynes has been developed, utilizing diboron as the borylation source for the efficient synthesis of alkenylborates. The reaction proceeds via cobalt‐boryl intermediates, diverging from conventional Co‐H chemistry. By fine‐tuning the phosphine ligand side chains, we achieved excellent reactivity and regioselectivity across a wide range of internal and terminal alkynes. This Co‐catalyzed method offers significant advantages in terms of both efficiency and environmental impact, making it an attractive approach for the synthesis of complex organic molecules.

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区域选择性钴催化炔的原硼化反应

研究了一种区域选择性钴催化的炔原硼化反应，利用二硼作为硼化源，高效合成了烯基硼酸盐。该反应通过钴-硼基中间体进行，与传统的Co - H化学反应不同。通过微调膦配体侧链，我们在广泛的内部和末端炔上获得了优异的反应性和区域选择性。这种Co催化方法在效率和环境影响方面具有显著的优势，使其成为合成复杂有机分子的一种有吸引力的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.