Epidemiology and risk factors of non-esophageal eosinophilic gastrointestinal diseases in Japan: A population-based study.

IF 6.2 2区医学 Q1 ALLERGY

Allergology International Pub Date : 2024-12-03 DOI:10.1016/j.alit.2024.10.007

Akinari Sawada, Takumi Imai, Yasutaka Ihara, Fumio Tanaka, Yasuhiro Fujiwara

{"title":"Epidemiology and risk factors of non-esophageal eosinophilic gastrointestinal diseases in Japan: A population-based study.","authors":"Akinari Sawada, Takumi Imai, Yasutaka Ihara, Fumio Tanaka, Yasuhiro Fujiwara","doi":"10.1016/j.alit.2024.10.007","DOIUrl":null,"url":null,"abstract":"Background: Non-esophageal eosinophilic gastrointestinal diseases (non-EoE EGIDs) are allergic conditions where Th-2-predominant inflammation causes symptoms related to gastrointestinal tract dysfunction. No studies have reported the incidence of non-EoE EGIDs. In addition, little is known about the influence of lifestyle factors on the condition.Methods: We used a large health claim database from January 2005 to September 2022. Non-EoE EGIDs cases were identified on the basis of the International Classification of Diseases-tenth Revision code, K52.8. The incidence and prevalence of non-EoE EGIDs were estimated by Poisson and binomial distribution, respectively. For each case, 10 controls were randomly selected for a nested case-control study to identify potential risk factors of non-EoE EGIDs.Results: Of 15,200,895 individuals, 1,368 new cases of non-EoE EGIDs were identified. The incidence and prevalence of non-EoE EGIDs in 2022 were 3.07 (95% CI 2.67-3.52) per 100,000 person-years and 17.23 (95% CI 16.38-18.11) per 100,000 individuals, respectively, which were approximately 6 and 9 times higher than those in 2010. Allergic rhinitis (OR 1.63 (95% CI 1.16-2.29), p = 0.005), chronic sinusitis (OR 2.41 (95% CI 1.58-3.66), p < 0.001), and urticaria (OR 2.32 (95% CI 1.45-3.70), p < 0.001) were related to an increased risk of adult non-EoE EGIDs. Whilst atopic dermatitis (OR 2.28 (95% CI 1.35-3.86), p = 0.006) and the perinatal factors (OR 3.68 (95% CI 1.13-12.02), p = 0.031) were associated with an increased risk of pediatric non-EoE EGIDs. No association was seen with lifestyle factors such as obesity, smoking and alcohol consumption.Conclusions: The incidence and prevalence of non-EoE EGIDs have increased over the past two decades.","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":" ","pages":""},"PeriodicalIF":6.2000,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Allergology International","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.alit.2024.10.007","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ALLERGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Non-esophageal eosinophilic gastrointestinal diseases (non-EoE EGIDs) are allergic conditions where Th-2-predominant inflammation causes symptoms related to gastrointestinal tract dysfunction. No studies have reported the incidence of non-EoE EGIDs. In addition, little is known about the influence of lifestyle factors on the condition.

Methods: We used a large health claim database from January 2005 to September 2022. Non-EoE EGIDs cases were identified on the basis of the International Classification of Diseases-tenth Revision code, K52.8. The incidence and prevalence of non-EoE EGIDs were estimated by Poisson and binomial distribution, respectively. For each case, 10 controls were randomly selected for a nested case-control study to identify potential risk factors of non-EoE EGIDs.

Results: Of 15,200,895 individuals, 1,368 new cases of non-EoE EGIDs were identified. The incidence and prevalence of non-EoE EGIDs in 2022 were 3.07 (95% CI 2.67-3.52) per 100,000 person-years and 17.23 (95% CI 16.38-18.11) per 100,000 individuals, respectively, which were approximately 6 and 9 times higher than those in 2010. Allergic rhinitis (OR 1.63 (95% CI 1.16-2.29), p = 0.005), chronic sinusitis (OR 2.41 (95% CI 1.58-3.66), p < 0.001), and urticaria (OR 2.32 (95% CI 1.45-3.70), p < 0.001) were related to an increased risk of adult non-EoE EGIDs. Whilst atopic dermatitis (OR 2.28 (95% CI 1.35-3.86), p = 0.006) and the perinatal factors (OR 3.68 (95% CI 1.13-12.02), p = 0.031) were associated with an increased risk of pediatric non-EoE EGIDs. No association was seen with lifestyle factors such as obesity, smoking and alcohol consumption.

Conclusions: The incidence and prevalence of non-EoE EGIDs have increased over the past two decades.

查看原文本刊更多论文

日本非食道嗜酸性粒细胞性胃肠道疾病的流行病学和危险因素：一项基于人群的研究

背景：非食道嗜酸性胃肠道疾病（non-EoE EGIDs）是一种以th -2为主的炎症引起胃肠道功能障碍相关症状的过敏性疾病。没有研究报道非eoe型egid的发生率。此外，人们对生活方式因素对这种疾病的影响知之甚少。方法：我们使用2005年1月至2022年9月的大型健康声明数据库。非eoe型egid病例是根据国际疾病分类第十次修订代码K52.8确定的。非eoe型EGIDs的发生率和患病率分别采用泊松分布和二项分布估计。对于每个病例，随机选择10名对照进行巢式病例对照研究，以确定非eoe EGIDs的潜在危险因素。结果：15200895例患者中，新发非eoe型egid 1,368例。2022年非eoe型EGIDs的发病率和患病率分别为3.07 (95% CI 2.67 ~ 3.52) / 10万人-年和17.23 (95% CI 16.38 ~ 18.11) / 10万人-年，分别比2010年高出约6倍和9倍。变应性鼻炎（OR 1.63 (95% CI 1.16-2.29), p = 0.005），慢性鼻窦炎(OR 2.41 (95% CI 1.58-3.66)， p结论：在过去二十年中，非eoe型egid的发病率和患病率有所增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Allergology International ALLERGY-IMMUNOLOGY

CiteScore

12.60

自引率

5.90%

发文量

审稿时长

29 weeks

期刊介绍： Allergology International is the official journal of the Japanese Society of Allergology and publishes original papers dealing with the etiology, diagnosis and treatment of allergic and related diseases. Papers may include the study of methods of controlling allergic reactions, human and animal models of hypersensitivity and other aspects of basic and applied clinical allergy in its broadest sense. The Journal aims to encourage the international exchange of results and encourages authors from all countries to submit papers in the following three categories: Original Articles, Review Articles, and Letters to the Editor.