A retrospective study of the aetiology of increased mean platelet volume in dogs presented to a small animal teaching hospital in Greece.

IF 1.3 Q2 VETERINARY SCIENCES

Veterinary Record Open Pub Date : 2024-12-03 eCollection Date: 2024-12-01 DOI:10.1002/vro2.70000

Ioannis L Oikonomidis, Harris Antoniadis, Afroditi Papathanasiou, Theodora K Tsouloufi, Timokleia Kousi, Maria Rafaella Kalafati, Maria Kritsepi-Konstantinou

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Abstract

Background: The aetiology of increased mean platelet volume in dogs is currently uncertain. Our aim was to investigate the aetiology of increased mean platelet volume in dogs with and without thrombocytopenia.

Methods: The database of a teaching hospital was retrospectively searched for dogs with increased mean platelet volume (>14.4 fL) over a 3-year period. Complete blood counts were performed with an Advia 120 analyser. Cases with incomplete medical records or belonging to breeds known to be associated with macrothrombocytopenia were excluded.

Results: Sixty-six dogs were included, with Group 1 consisting of non-thrombocytopenic dogs (49/66, 74.2%) and Group 2 consisting of thrombocytopenic dogs (17/66, 25.8%). Diagnoses significantly differed between the two groups (p = 0.003). In Group 1, inflammatory/infectious diseases (69.4%) were the most common cause, followed by neoplastic diseases (8.2%) and diabetes mellitus (6.1%). Dogs in Group 2 were diagnosed with either inflammatory/infectious diseases (50.0%) or neoplastic diseases (50.0%). The small sample size- and a potential delayed haematological analysis of some of the blood samples, could have artifactually affected the mean platelet volume.

Conclusions: In dogs with thrombocytopenia and increased mean platelet volume, inflammatory/infectious or neoplastic diseases should be considered. In non-thrombocytopenic dogs, increased mean platelet volume is primarily associated with inflammatory/infectious diseases, with neoplasia and diabetes mellitus being infrequent causes.

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希腊一家小动物教学医院对犬平均血小板体积增加的病因进行回顾性研究。

背景：犬平均血小板体积增加的病因目前尚不确定。我们的目的是研究有和没有血小板减少症的狗平均血小板体积增加的原因。方法：回顾性检索某教学医院数据库，查找3年内平均血小板体积（>14.4 fL）升高的犬。使用Advia 120分析仪进行全血细胞计数。医疗记录不完整或属于已知与巨血小板减少症相关的品种的病例被排除在外。结果：共纳入66只犬，其中1组为非血小板减少犬（49/66,74.2%），2组为血小板减少犬（17/66,25.8%）。两组诊断差异有统计学意义（p = 0.003）。在第1组中，炎症/感染性疾病（69.4%）是最常见的原因，其次是肿瘤（8.2%）和糖尿病（6.1%）。第2组犬诊断为炎症/感染性疾病（50.0%）或肿瘤疾病（50.0%）。小样本量——以及对一些血液样本可能延迟的血液学分析——可能人为地影响了平均血小板体积。结论：对于血小板减少和平均血小板体积增加的狗，应考虑炎症/感染性或肿瘤疾病。在非血小板减少性犬中，平均血小板体积增加主要与炎症/感染性疾病有关，肿瘤和糖尿病是罕见的原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Veterinary Record Open VETERINARY SCIENCES-

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

19 weeks

期刊介绍： Veterinary Record Open is a journal dedicated to publishing specialist veterinary research across a range of topic areas including those of a more niche and specialist nature to that considered in the weekly Vet Record. Research from all disciplines of veterinary interest will be considered. It is an Open Access journal of the British Veterinary Association.