Exploring the innovative application of cerium oxide nanoparticles for addressing oxidative stress in ovarian tissue regeneration.

IF 3.8 3区 医学 Q1 REPRODUCTIVE BIOLOGY
Maya Lakshmanan, Monika Saini, Manasa Nune
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Abstract

The female reproductive system dysfunction considerably affects the overall health of women and children on a global scale. Over the decade, the incidence of reproductive disorders has become a significant source of suffering for women. Infertility in women may be caused by a range of acquired and congenital abnormalities. Ovaries play a central role in the female reproductive function. Any defect in the normal functioning of these endocrine organs causes health issues and reproductive challenges extending beyond infertility, as the hormones interact with other tissues and biological processes in the body. The complex pathophysiology of ovarian disorders makes it a multifactorial disease. The key etiological factors associated with the diseases include genetic factors, hormonal imbalance, environmental and lifestyle factors, inflammatory conditions, oxidative stress, autoimmune diseases, metabolic factors, and age. Oxidative stress is a major contributor to disease development and progression affecting the oocyte quality, fertilization, embryo development, and implantation. The choice of treatment for ovarian disorders varies among individuals and has associated complications. Reproductive tissue engineering holds great promise for overcoming the challenges associated with the current therapeutic approach to tissue regeneration. Furthermore, incorporating nanotechnology into tissue engineering could offer an efficient treatment strategy. This review provides an overview of incorporating antioxidant nanomaterials for engineering ovarian tissue to address the disease recurrence and associated pathophysiology. Cerium oxide nanoparticles (CeO2 NPs) are prioritized for evaluation primarily due to their antioxidant properties. In conclusion, the review explores the potential applications of CeO2 NPs for effective and clinically significant ovarian tissue regeneration.

探索氧化铈纳米颗粒在卵巢组织再生中解决氧化应激的创新应用。
在全球范围内,女性生殖系统功能障碍严重影响妇女和儿童的整体健康。十年来,生殖疾病的发病率已成为妇女痛苦的一个重要来源。女性不孕症可能由一系列后天和先天异常引起。卵巢在女性生殖功能中起着核心作用。由于激素与体内其他组织和生物过程相互作用,这些内分泌器官正常功能的任何缺陷都会导致健康问题和生殖挑战,而不仅仅是不孕不育。卵巢疾病的复杂病理生理使其成为一种多因素疾病。与这些疾病相关的主要病因包括遗传因素、激素失衡、环境和生活方式因素、炎症条件、氧化应激、自身免疫性疾病、代谢因素和年龄。氧化应激是影响卵母细胞质量、受精、胚胎发育和着床的疾病发生和进展的主要因素。卵巢疾病的治疗选择因人而异,并有相关的并发症。生殖组织工程在克服与当前组织再生治疗方法相关的挑战方面具有很大的希望。此外,将纳米技术结合到组织工程中可以提供一种有效的治疗策略。本文综述了抗氧化纳米材料在卵巢组织工程中的应用,以解决疾病复发和相关病理生理问题。氧化铈纳米颗粒(CeO2 NPs)主要由于其抗氧化性能而被优先评估。综上所述,本文探讨了CeO2 NPs在卵巢组织再生中的潜在应用。
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来源期刊
Journal of Ovarian Research
Journal of Ovarian Research REPRODUCTIVE BIOLOGY-
CiteScore
6.20
自引率
2.50%
发文量
125
审稿时长
>12 weeks
期刊介绍: Journal of Ovarian Research is an open access, peer reviewed, online journal that aims to provide a forum for high-quality basic and clinical research on ovarian function, abnormalities, and cancer. The journal focuses on research that provides new insights into ovarian functions as well as prevention and treatment of diseases afflicting the organ. Topical areas include, but are not restricted to: Ovary development, hormone secretion and regulation Follicle growth and ovulation Infertility and Polycystic ovarian syndrome Regulation of pituitary and other biological functions by ovarian hormones Ovarian cancer, its prevention, diagnosis and treatment Drug development and screening Role of stem cells in ovary development and function.
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