The Study Progress and Analysis of Preventive Measures of Nursing Care for Chemotherapy-Induced Oral Mucositis in Pediatric Patients with Hematologic Malignancies: A Retrospective Study.

IF 2.7 3区 医学 Q2 HEALTH CARE SCIENCES & SERVICES
Journal of Multidisciplinary Healthcare Pub Date : 2024-11-30 eCollection Date: 2024-01-01 DOI:10.2147/JMDH.S489003
Ying Gu, Ning Chen, Min He, Duo Zheng, Juan Liu, Xia-Ling Fang
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引用次数: 0

Abstract

Objective: To analyze the preventive and therapeutic effects of comprehensive nursing interventions on chemotherapy-induced oral mucositis in pediatric patients with hematologic malignancies.

Methods: A retrospective analysis was conducted, and 80 pediatric patients with hematologic malignancies who underwent chemotherapy in our hospital from January 2020 to December 2023 were selected as the research subjects. According to different nursing intervention methods, the patients were divided into an experimental group (45 cases) and a control group (35 cases). The experimental group received comprehensive nursing interventions, including oral care, dietary guidance, and psychological support; the control group received routine care. The observation indicators included the incidence of oral mucositis, Oral Mucositis Daily Questionnaire (OMDQ) scores, pain index (Visual Analog Scale), and levels of inflammatory markers (IL-6 and CRP) in saliva.

Results: In the first, second, and fourth weeks of chemotherapy, the incidence of oral mucositis in the experimental group was significantly lower than in the control group (P < 0.05), with a total incidence of 51.11% compared to 77.14% (P = 0.017). Before chemotherapy, no significant difference was observed in OMDQ or VAS scores between the groups (p>0.05). However, in the first, second, and fourth weeks, OMDQ and VAS scores in the experimental group were significantly lower than those in the control group (P < 0.001). Similarly, levels of IL-6 and CRP showed no baseline difference between groups but were significantly reduced in the experimental group during these weeks (P < 0.001).

Conclusion: Comprehensive nursing interventions significantly reduce the incidence and severity of chemotherapy-induced oral mucositis in pediatric patients with hematologic malignancies, alleviate oral pain in pediatric patients, and effectively reduce the levels of inflammatory markers in saliva. The application of comprehensive nursing interventions in clinical nursing practice can improve the quality of care for pediatric patients with hematologic malignancies.

儿童恶性血液病患者化疗所致口腔黏膜炎的护理预防措施及研究进展回顾性分析。
目的:分析综合护理干预对儿科恶性血液病患者化疗所致口腔黏膜炎的防治效果。方法:回顾性分析,选取2020年1月至2023年12月在我院接受化疗的80例儿科血液恶性肿瘤患者作为研究对象。根据护理干预方式的不同,将患者分为实验组(45例)和对照组(35例)。实验组患者给予口腔护理、饮食指导、心理支持等综合护理干预;对照组接受常规护理。观察指标包括口腔黏膜炎发生率、口腔黏膜炎日常问卷(OMDQ)评分、疼痛指数(视觉模拟量表)、唾液炎症标志物(IL-6、CRP)水平。结果:化疗第1、2、4周,试验组口腔黏膜炎发生率显著低于对照组(P < 0.05),总发生率为51.11%,对照组为77.14% (P = 0.017)。化疗前,两组患者的OMDQ、VAS评分比较,差异均无统计学意义(p < 0.05)。但在第1、2、4周,实验组的OMDQ和VAS评分均显著低于对照组(P < 0.001)。同样,各组之间IL-6和CRP水平无基线差异,但实验组在这几周内显著降低(P < 0.001)。结论:综合护理干预可显著降低儿科血液学恶性肿瘤患者化疗所致口腔黏膜炎的发生率和严重程度,减轻儿科患者口腔疼痛,有效降低唾液炎症标志物水平。综合护理干预在临床护理实践中的应用,可以提高儿科血液系统恶性肿瘤患者的护理质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Multidisciplinary Healthcare
Journal of Multidisciplinary Healthcare Nursing-General Nursing
CiteScore
4.60
自引率
3.00%
发文量
287
审稿时长
16 weeks
期刊介绍: The Journal of Multidisciplinary Healthcare (JMDH) aims to represent and publish research in healthcare areas delivered by practitioners of different disciplines. This includes studies and reviews conducted by multidisciplinary teams as well as research which evaluates or reports the results or conduct of such teams or healthcare processes in general. The journal covers a very wide range of areas and we welcome submissions from practitioners at all levels and from all over the world. Good healthcare is not bounded by person, place or time and the journal aims to reflect this. The JMDH is published as an open-access journal to allow this wide range of practical, patient relevant research to be immediately available to practitioners who can access and use it immediately upon publication.
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