Brain Reactivity and Vulnerability to Social Feedback Following Acute Stress in Early Adolescence

IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES
Zeynep Celen, Ryan J. Murray, Mariana Magnus Smith, Sondes Jouabli, Vladimira Ivanova, Eleonore Pham, Zoe Schilliger, Patrik Vuilleumier, Arnaud Merglen, Paul Klauser, Camille Piguet
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Abstract

Introduction

Early adolescence is a time of high psychosocial stress exposure and high stress reactivity, associated with the development of mental disorders. Understanding how the brain reacts to acute and social stressors during this period might help us detect and protect those at risk.

Methods

We used functional magnetic resonance imaging to investigate acute social stress reactivity in non-clinical adolescents between ages 13 and 15 years (N = 61) with a range of depression scores (Beck Depression Inventory scores 0–32). Participants underwent a modified Montreal Imaging Stress Task (MIST) with psychosocial stress condition consisting of two parts: acute stress (challenging maths) followed by social feedback (positive or negative), separated by brief recovery periods. The test condition was compared to a non-stressful control. We examined brain responses to social feedback relative to the acute stressor and feedback valence.

Results

Psychosocial stress produced differential activation in the paracingulate gyrus, insula, and deactivation in the ventral striatum. Receiving social feedback, compared to acute stress, activated cortical midline regions such as the medial prefrontal cortex and posterior cingulate cortex. Positive feedback increased activity in frontal pole and middle frontal gyrus whereas negative feedback did not show any differential response in the whole group. However, participants with depressive symptoms reacted with higher activation in the posterior cingulate cortex to negative feedback.

Conclusion

We show that social feedback after an acute stressor activates regions involved in self-referential processing, with positive feedback eliciting generally higher activation and negative feedback impacting only individuals with vulnerable mood traits during early adolescence.

Abstract Image

青少年早期急性应激后的大脑反应性和社会反馈脆弱性。
青少年早期是高心理社会压力暴露和高应激反应的时期,与精神障碍的发展有关。了解大脑在这一时期对急性和社会压力源的反应,可能有助于我们发现并保护那些处于危险中的人。方法:采用功能性磁共振成像技术对年龄在13 ~ 15岁之间的非临床青少年(N = 61)进行急性社会应激反应性调查,这些青少年的抑郁评分范围为贝克抑郁量表评分0 ~ 32分。参与者接受了一项改良的蒙特利尔成像压力任务(MIST),其心理社会压力状况由两部分组成:急性压力(挑战数学),然后是社会反馈(积极或消极),中间间隔着短暂的恢复期。将测试条件与无压力对照进行比较。我们研究了大脑对社会反馈的反应与急性应激源和反馈效价的关系。结果:社会心理压力在扣带回和脑岛产生不同程度的激活,在腹侧纹状体产生不同程度的失活。与急性应激相比,接受社会反馈激活了皮层中线区域,如内侧前额叶皮层和后扣带皮层。正反馈增加了额极和额中回的活动,而负反馈在整个组中没有表现出任何差异反应。然而,有抑郁症状的参与者对负面反馈的后扣带皮层反应更活跃。结论:我们发现急性应激源后的社会反馈激活了涉及自我参照加工的区域,积极反馈引起普遍较高的激活,而消极反馈仅影响青春期早期情绪特征脆弱的个体。
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来源期刊
Brain and Behavior
Brain and Behavior BEHAVIORAL SCIENCES-NEUROSCIENCES
CiteScore
5.30
自引率
0.00%
发文量
352
审稿时长
14 weeks
期刊介绍: Brain and Behavior is supported by other journals published by Wiley, including a number of society-owned journals. The journals listed below support Brain and Behavior and participate in the Manuscript Transfer Program by referring articles of suitable quality and offering authors the option to have their paper, with any peer review reports, automatically transferred to Brain and Behavior. * [Acta Psychiatrica Scandinavica](https://publons.com/journal/1366/acta-psychiatrica-scandinavica) * [Addiction Biology](https://publons.com/journal/1523/addiction-biology) * [Aggressive Behavior](https://publons.com/journal/3611/aggressive-behavior) * [Brain Pathology](https://publons.com/journal/1787/brain-pathology) * [Child: Care, Health and Development](https://publons.com/journal/6111/child-care-health-and-development) * [Criminal Behaviour and Mental Health](https://publons.com/journal/3839/criminal-behaviour-and-mental-health) * [Depression and Anxiety](https://publons.com/journal/1528/depression-and-anxiety) * Developmental Neurobiology * [Developmental Science](https://publons.com/journal/1069/developmental-science) * [European Journal of Neuroscience](https://publons.com/journal/1441/european-journal-of-neuroscience) * [Genes, Brain and Behavior](https://publons.com/journal/1635/genes-brain-and-behavior) * [GLIA](https://publons.com/journal/1287/glia) * [Hippocampus](https://publons.com/journal/1056/hippocampus) * [Human Brain Mapping](https://publons.com/journal/500/human-brain-mapping) * [Journal for the Theory of Social Behaviour](https://publons.com/journal/7330/journal-for-the-theory-of-social-behaviour) * [Journal of Comparative Neurology](https://publons.com/journal/1306/journal-of-comparative-neurology) * [Journal of Neuroimaging](https://publons.com/journal/6379/journal-of-neuroimaging) * [Journal of Neuroscience Research](https://publons.com/journal/2778/journal-of-neuroscience-research) * [Journal of Organizational Behavior](https://publons.com/journal/1123/journal-of-organizational-behavior) * [Journal of the Peripheral Nervous System](https://publons.com/journal/3929/journal-of-the-peripheral-nervous-system) * [Muscle & Nerve](https://publons.com/journal/4448/muscle-and-nerve) * [Neural Pathology and Applied Neurobiology](https://publons.com/journal/2401/neuropathology-and-applied-neurobiology)
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