Elevated whole blood viscosity is associated with an impaired insulin-stimulated myocardial glucose metabolism.

IF 8.5 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Elena Succurro, Patrizia Vizza, Francesco Cicone, Mariangela Rubino, Teresa Vanessa Fiorentino, Maria Perticone, Gaia Chiara Mannino, Angela Sciacqua, Pietro Hiram Guzzi, Pierangelo Veltri, Giuseppe Lucio Cascini, Francesco Andreozzi, Giorgio Sesti
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Abstract

Background: Increased whole blood viscosity (WBV) was associated with impaired peripheral glucose metabolism, type 2 diabetes, and cardiovascular disease (CVD). Impaired myocardial glucose metabolism is a risk factor for CVD. Whether an increased WBV is associated with impaired myocardial glucose metabolism is still undefined.

Methods: To elucidate this issue, we evaluated the association between WBV and myocardial glucose metabolic rate (MRGlu) in 57 individuals with different glucose tolerance status. Myocardial MRGlu was assessed using dynamic cardiac 18F-FDG PET combined with euglycemic hyperinsulinemic clamp. WBV was calculated using a validated equation including hematocrit and plasma proteins: WBV = [0.12 × h] + [0.17 × (p - 2.07)], where h is the hematocrit (%) and p the plasma proteins (g/dl). The subjects were stratified into tertiles according to their myocardial MrGlu values.

Results: As compared with individuals in the highest myocardial MrGlu tertile, those in the lowest tertile showed an age-adjusted increase in WBV (5.54 ± 0.3 cP vs. 6.13 ± 0.4 cP respectively; P = 0.001), hematocrit (39.1 ± 3.1% vs. 43.2 ± 3.7% respectively; P = 0.004), and total proteins (7.06 ± 0.3 g/l vs. 7.60 ± 0.3 g/l respectively; P < 0.0001). WBV was negatively correlated with myocardial MRGlu (r = - 0.416, P = 0.001). In a stepwise multivariate regression analysis, including several cardiovascular risk factors, the only variables significantly associated with myocardial MrGlu were WBV (β - 0.505; P < 0.0001), fasting insulin (β - 0.346; P = 0.004), fasting plasma glucose (β - 0.287; P = 0.01), and sex (β 0.280; P = 0.003) explaining the 69.6% of its variation.

Conclusions: The current study showed a strongly association between an increase of WBV and an impaired myocardial glucose metabolism in individuals with a broad spectrum of glucose tolerance.

全血粘度升高与胰岛素刺激的心肌葡萄糖代谢受损有关。
背景:全血粘度(WBV)升高与外周糖代谢受损、2型糖尿病和心血管疾病(CVD)有关。心肌糖代谢受损是心血管疾病的危险因素。WBV升高是否与心肌糖代谢受损有关尚不清楚。方法:为了阐明这一问题,我们评估了57例不同糖耐量状态的个体的WBV与心肌糖代谢率(MRGlu)之间的关系。心肌MRGlu评估采用动态心脏18F-FDG PET联合正糖高胰岛素钳。WBV的计算采用一个经过验证的公式,包括血细胞比容和血浆蛋白:WBV = [0.12 × h] + [0.17 × (p - 2.07)],其中h为血细胞比容(%),p为血浆蛋白(g/dl)。根据心肌MrGlu值将受试者分层。结果:与心肌MrGlu最高组相比,最低组WBV随年龄变化增加(5.54±0.3 cP vs. 6.13±0.4 cP);P = 0.001),红细胞比容(39.1±3.1%和43.2±3.7%;P = 0.004),总蛋白(7.06±0.3 g/l vs. 7.60±0.3 g/l);结论:目前的研究表明,在广谱糖耐量个体中,WBV增加与心肌糖代谢受损之间存在强烈关联。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cardiovascular Diabetology
Cardiovascular Diabetology 医学-内分泌学与代谢
CiteScore
12.30
自引率
15.10%
发文量
240
审稿时长
1 months
期刊介绍: Cardiovascular Diabetology is a journal that welcomes manuscripts exploring various aspects of the relationship between diabetes, cardiovascular health, and the metabolic syndrome. We invite submissions related to clinical studies, genetic investigations, experimental research, pharmacological studies, epidemiological analyses, and molecular biology research in this field.
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