Potential of boron neutron capture therapy (BNCT) for myxofibrosarcoma

IF 1.6 3区工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Applied Radiation and Isotopes Pub Date : 2024-11-26 DOI:10.1016/j.apradiso.2024.111603

Takuya Fujimoto , Tooru Andoh , Tamotsu Sudo , Ikuo Fujita , Yoshinori Sakurai , Takushi Takata , Hiroki Tanaka , Teruya Kawamoto , Shunsuke Yahiro , Shotaro Nakamura , Hitomi Hara , Naomasa Fukase , Toshihiro Akisue , Hideki Ichikawa , Ryosuke Kuroda , Minoru Suzuki

引用次数: 0

Abstract

Myxofibrosarcoma, a rare malignant tumor, predominantly affects the extremities of the elderly. Because of its invasive nature amputation is sometimes required, resulting in serious deterioration of quality of life. Therefore, cell lines established from amputated surgical specimens of myxofibrosarcoma in the upper limbs of elderly patients were used to create a myxofibrosarcoma-bearing animal model and to investigate the therapeutic effect of BNCT thereon. The results demonstrated selective destruction of tumor cells, suggesting the anti-tumor efficacy of BNCT on myxofibrosarcoma.

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硼中子俘获治疗黏液纤维肉瘤的潜力。

黏液纤维肉瘤是一种罕见的恶性肿瘤，主要影响老年人的四肢。由于其侵入性，有时需要截肢，导致生活质量严重下降。因此，我们利用老年患者上肢黏液纤维肉瘤手术切除标本建立细胞系，建立载黏液纤维肉瘤动物模型，并研究BNCT对其治疗效果。结果显示BNCT对黏液纤维肉瘤具有选择性破坏作用，提示BNCT对黏液纤维肉瘤具有抗肿瘤作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Applied Radiation and Isotopes 工程技术-核科学技术

CiteScore

3.00

自引率

12.50%

发文量

406

审稿时长

13.5 months

期刊介绍： Applied Radiation and Isotopes provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and peaceful application of nuclear, radiation and radionuclide techniques in chemistry, physics, biochemistry, biology, medicine, security, engineering and in the earth, planetary and environmental sciences, all including dosimetry. Nuclear techniques are defined in the broadest sense and both experimental and theoretical papers are welcome. They include the development and use of α- and β-particles, X-rays and γ-rays, neutrons and other nuclear particles and radiations from all sources, including radionuclides, synchrotron sources, cyclotrons and reactors and from the natural environment. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. Papers dealing with radiation processing, i.e., where radiation is used to bring about a biological, chemical or physical change in a material, should be directed to our sister journal Radiation Physics and Chemistry.