Fecal microbiota transplantation as an effective way in treating methylmercury-poisoned rats.

IF 8 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Science of the Total Environment Pub Date : 2024-12-20 Epub Date: 2024-12-03 DOI:10.1016/j.scitotenv.2024.177850

Yanfei Zhang, Qingxuan Liu, Hongxin Xie, Wei Zhang, Xiaoying Lin, Huifeng Zhang, Huan Yu, Yinghui Ma, Chuang Zhang, Hao Geng, Nianqiu Shi, Liwei Cui, Bai Li, Yu-Feng Li

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引用次数: 0

Abstract

Methylmercury (MeHg) can cause devastating neurotoxicity in animals and human beings. Gut microbiota dysbiosis has been found in MeHg-poisoned animals. Fecal microbiota transplantation (FMT) has been shown to improve clinical outcomes in a variety of diseases such as epilepsy, amyotrophic lateral sclerosis (ALS) and autism. The aim of this study was to investigate the effects of FMT on MeHg-poisoned rats. FMT treatment was applied to MeHg-poisoned rats for 14 days. The neurobehavior, weight changes, dopamine (DA), the total Hg and MeHg level were evaluated. Besides, the gut microbiota and metabolites change in feces were also checked. It was found that FMT helped weight gain, alleviated the neurological disorders, enhanced fecal mercury excretion and MeHg demethylation, reconstructed gut microbiome and promoted the production of gut-brain axis related-metabolites in MeHg-poisoned rats. This study elaborates on the therapeutic efficacy of FMT in treating of MeHg-poisoned rats, which sheds lights on the treatment of neurological diseases like Minamata Disease and even Parkinson's Disease.

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粪便微生物群移植作为治疗甲基汞中毒大鼠的有效方法。

甲基汞（MeHg）可对动物和人类造成毁灭性的神经毒性。在汞中毒的动物中发现了肠道菌群失调。粪便微生物群移植（FMT）已被证明可以改善癫痫、肌萎缩侧索硬化症（ALS）和自闭症等多种疾病的临床结果。本研究旨在探讨FMT对甲基汞中毒大鼠的影响。mhg中毒大鼠给予FMT治疗14 d。观察大鼠神经行为、体重变化、多巴胺（DA）、总汞（Hg）和甲汞柱（MeHg）水平。此外，还检查了肠道菌群和粪便中代谢物的变化。结果发现，FMT有助于甲基汞中毒大鼠体重增加，缓解神经系统疾病，促进粪便汞排泄和甲基汞去甲基化，重建肠道微生物群，促进肠-脑轴相关代谢物的产生。本研究详细阐述了FMT对甲基汞中毒大鼠的治疗效果，为水俣病甚至帕金森病等神经系统疾病的治疗提供了新的思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science of the Total Environment 环境科学-环境科学

CiteScore

17.60

自引率

10.20%

发文量

8726

审稿时长

2.4 months

期刊介绍： The Science of the Total Environment is an international journal dedicated to scientific research on the environment and its interaction with humanity. It covers a wide range of disciplines and seeks to publish innovative, hypothesis-driven, and impactful research that explores the entire environment, including the atmosphere, lithosphere, hydrosphere, biosphere, and anthroposphere. The journal's updated Aims & Scope emphasizes the importance of interdisciplinary environmental research with broad impact. Priority is given to studies that advance fundamental understanding and explore the interconnectedness of multiple environmental spheres. Field studies are preferred, while laboratory experiments must demonstrate significant methodological advancements or mechanistic insights with direct relevance to the environment.

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