An l-cysteine based sensor for Cu2+ detection applicable for both environmental water and human plasma†

IF 2.7 3区 化学 Q2 CHEMISTRY, ANALYTICAL
Yanhong Chen, Li Lv, Xuanjiao Mao, Jun Chai, Jayne Wu, Yicheng Zhou, Jian Zhang and Haochen Qi
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Abstract

A flexible electrochemical sensor with high sensitivity and specificity is developed using gold nanoparticles (AuNPs) and a reduced graphene oxide/molybdenum disulfide (rGo–MoS2) composite modified screen printed carbon electrode (SPCE), with L-cysteine (L-Cys) as a probe for Cu2+ target recognition. Owing to the AuNPs/rGo–MoS2, the electron transference ability is improved by increasing the specific surface area of the working electrode, and a high sensitivity is achieved. Meanwhile, the bidentate chelation of L-Cys to Cu2+ contributes to a good selectivity. Using differential pulse voltammetry (DPV) for spiked standard Cu2+, the test results show a dynamic range from 0.1 μM to 100 μM, a detection limit of 0.020 μM, and a high sensitivity of 1.190 μA μM−1. Furthermore, detection in both environmental water and human plasma samples demonstrates a wide applicability of this sensor in various matrices, and an excellent feasibility for environmental and clinical applications.

Abstract Image

一种基于l -半胱氨酸的Cu2+检测传感器,适用于环境水和人体血浆。
采用金纳米粒子(AuNPs)和还原氧化石墨烯/二硫化钼(rGo-MoS2)复合修饰的丝网印刷碳电极(SPCE),以l -半胱氨酸(L-Cys)作为Cu2+目标识别探针,开发了一种高灵敏度和特异性的柔性电化学传感器。由于AuNPs/rGo-MoS2,通过增加工作电极的比表面积,提高了电子转移能力,并实现了高灵敏度。同时,L-Cys与Cu2+的双齿螯合使其具有良好的选择性。采用差分脉冲伏安法(DPV)对标准Cu2+进行加标,动态范围为0.1 μM ~ 100 μM,检出限为0.020 μM,灵敏度为1.190 μA μM-1。此外,在环境水和人体血浆样品中的检测表明,该传感器在各种基质中具有广泛的适用性,并且在环境和临床应用方面具有良好的可行性。
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来源期刊
Analytical Methods
Analytical Methods CHEMISTRY, ANALYTICAL-FOOD SCIENCE & TECHNOLOGY
CiteScore
5.10
自引率
3.20%
发文量
569
审稿时长
1.8 months
期刊介绍: Early applied demonstrations of new analytical methods with clear societal impact
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