Mesogenic Architectures for Advanced Drug Delivery: Interrogating Lyotropic and Thermotropic Liquid Crystals

IF 3.4 4区医学 Q2 PHARMACOLOGY & PHARMACY

AAPS PharmSciTech Pub Date : 2024-12-05 DOI:10.1208/s12249-024-02985-6

Induja Govindan, Angeeta Paul, Annamalai Rama, Anjana A. Kailas, K. A. Abutwaibe, Thamizharasan Annadurai, Anup Naha

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Abstract

The possibility of precisely regulating and targeting drug release with mesophase or Liquid crystal drug delivery systems has drawn much attention recently. This review offers a thorough investigation of liquid crystal drug delivery systems with an emphasis on their mesogenic architecture. It describes the various liquid crystal forms such as thermotropic and lyotropic liquid crystals and their applicability in advanced drug delivery. Liquid crystals are used as excellent carriers due to their distinctive characteristics, such as stimuli-responsive drug delivery and sustained release patterns. Comprehending the materials that form mesophase provides insight into their distinct physiochemical characteristics and their use in drug delivery. This review highlights the important role lyotropic and thermotropic liquid crystals play in drug delivery, underscoring their considerable potential. The transition of thermotropic liquid crystals from their conventional technological applications to drug delivery has been studied. Nonetheless, a few challenges still need to be addressed, including formulation strategy refinement, regulating release rates, maximising the loading of hydrophilic drugs, and storage stability. In the pharmaceutical field, addressing these issues will open the door to a revolutionary paradigm that will revolutionise therapeutic outcomes and improve patient care.

Graphical Abstract

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先进药物传递的介观结构：溶致性和热致性液晶的研究

利用中相或液晶给药系统精确调控和靶向药物释放的可能性近年来受到广泛关注。本文综述了液晶给药系统的研究进展，重点介绍了液晶给药系统的介源结构。介绍了热致液晶和溶致液晶等各种液晶形态及其在高级给药中的适用性。液晶由于其独特的特性，如刺激反应性药物传递和持续释放模式，被用作优秀的载体。了解形成中间相的物质，可以深入了解它们独特的物理化学特性及其在药物传递中的应用。本文综述了热致性和溶性液晶在药物传递中的重要作用，强调了它们的巨大潜力。研究了热致液晶从传统技术应用到药物传递的转变。尽管如此，仍有一些挑战需要解决，包括配方策略的改进，调节释放率，最大限度地增加亲水药物的负荷，以及储存稳定性。在制药领域，解决这些问题将为一种革命性的范式打开大门，这种范式将彻底改变治疗结果并改善患者护理。图形抽象

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来源期刊

AAPS PharmSciTech 医学-药学

CiteScore

6.80

自引率

3.00%

发文量

264

审稿时长

2.4 months

期刊介绍： AAPS PharmSciTech is a peer-reviewed, online-only journal committed to serving those pharmaceutical scientists and engineers interested in the research, development, and evaluation of pharmaceutical dosage forms and delivery systems, including drugs derived from biotechnology and the manufacturing science pertaining to the commercialization of such dosage forms. Because of its electronic nature, AAPS PharmSciTech aspires to utilize evolving electronic technology to enable faster and diverse mechanisms of information delivery to its readership. Submission of uninvited expert reviews and research articles are welcomed.