Synthesis of functionalized N-acylated amino acids containing 3- and 4-coordinated phosphorus moieties

Abstract

A convenient synthesis of functionalized N-acylated amino acids containing 3- and 4-coordinated phosphorus moieties as well as N-alkoxycarbonyl groups has been developed. Aminomethylation of tricoordinated phosphorus acid esters with N-chloromethylsubstituted N-alkoxycarbonylamino acids proceeds under mild conditions and affords new types of target products of different structures. The resulting compounds are of interest as promising biologically active substances, effective extractants, and water-soluble polydentate ligands.