Exploring green solvent systems and enhanced solubility of xanthone in triglyceride-based tricaprin-tricaprylin mixtures with thermodynamic insights

IF 4.3 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

BMC Chemistry Pub Date : 2024-12-04 DOI:10.1186/s13065-024-01329-6

Hua Liu, Johnson Stanslas, Jiaoyan Ren, Norhidayah Binti Suleiman, Gun Hean Chong

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Abstract

This study explores the use of green solvent systems by investigating the solubility and thermodynamic properties of xanthone (1) in triglyceride-based tricaprin (2) and tricaprylin (3) mixtures, aiming to replace traditional organic solvents. The solubility profile exhibited a concave trend, and the highest solubility was observed at a solute-free fraction (x₂) of 0.36. The solubility exponentially increased with increasing temperature in the range from 30 °C to 75 °C. The solubility data were effectively correlated using the local composition-regular solution theory (LC-RST) model and achieved an ARDln value of 4.8 × 10^–3. The model indicated strong interactions between tricaprin and tricaprylin, followed by interactions between tricaprylin and xanthone and between tricaprin and xanthone. The dissolution process of xanthone was primarily enthalpy driven. Based on the structural analysis, xanthone maintained its molecular structure after dissolution in tricaprin and tricaprylin; however, changes in crystallinity levels were observed. These findings provide insights into the use of triglycerides as solvents to improve the solubility and bioaccessibility of hydrophobic compounds such as xanthone.

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来源期刊

BMC Chemistry Chemistry-General Chemistry

CiteScore

5.30

自引率

2.20%

发文量

审稿时长

27 weeks

期刊介绍： BMC Chemistry, formerly known as Chemistry Central Journal, is now part of the BMC series journals family. Chemistry Central Journal has served the chemistry community as a trusted open access resource for more than 10 years – and we are delighted to announce the next step on its journey. In January 2019 the journal has been renamed BMC Chemistry and now strengthens the BMC series footprint in the physical sciences by publishing quality articles and by pushing the boundaries of open chemistry.