Novel Polyvinyl Alcohol: Polyacrylic Acid Nanofiber Composite for Prolonged Release of Capecitabine: In Vitro and In Vivo Evaluations of Colon-Targeted Drug Delivery

IF 2.2 4区工程技术 Q1 MATERIALS SCIENCE, TEXTILES

Fibers and Polymers Pub Date : 2024-11-14 DOI:10.1007/s12221-024-00770-7

Padmaja SidramGiram, Swami Shailesh, Omprakash Gadgeppa Bhusnure, Sachin Sivajirao Pandit, Selvaraja Elumalai, Ubaidulla Uthumansha, Jang Hyun Tae, Ganesh Mani

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Abstract

Cancer is a leading cause of death in the world. Recent research studies have mainly focused on available treatments without problems. Recently, advances in nanotechnology have revolutionized the way that pharmaceuticals are given, reducing their negative effects. Electrospun nanofibers are unique among the colon-focused drug delivery technology in terms of their high biocompatibility and tunable drug-release profiles. The present study aimed to develop capecitabine (CPB)-loaded nanofibers (NFs) using a composite of polyvinyl alcohol (PVA) and polyacrylic acid (PAA) to achieve controlled release at colonic pH. A maximum drug-release rate of 91.92% was achieved with formulated nanofibers having a diameter of 591.38 nm. Results of in vitro release by NFs showed a burst release pattern at the initial stage followed by prolonged release for up to 20 h. In vitro cell cytotoxicity studies revealed high cytotoxicity of formulated NFs against HT-29 colon carcinoma. Formulated NFs also showed improved in vivo anti-cancer activity compared to free drug. Therapeutic efficacy of CPB NFs was superior compared to free drug in treating cancer in induced rats.

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来源期刊

Fibers and Polymers 工程技术-材料科学：纺织

CiteScore

3.90

自引率

8.00%

发文量

267

审稿时长

3.9 months

期刊介绍： -Chemistry of Fiber Materials, Polymer Reactions and Synthesis- Physical Properties of Fibers, Polymer Blends and Composites- Fiber Spinning and Textile Processing, Polymer Physics, Morphology- Colorants and Dyeing, Polymer Analysis and Characterization- Chemical Aftertreatment of Textiles, Polymer Processing and Rheology- Textile and Apparel Science, Functional Polymers