Network Meta-analysis of the clinical efficacy and safety of kidney-tonifying and bone-strengthening therapies for the treatment of rheumatoid arthritis with kidney deficiency type.
Gan Chang, Tao Qingwen, Y I Haoying, Bian Yuting, Wang Jianming
{"title":"Network Meta-analysis of the clinical efficacy and safety of kidney-tonifying and bone-strengthening therapies for the treatment of rheumatoid arthritis with kidney deficiency type.","authors":"Gan Chang, Tao Qingwen, Y I Haoying, Bian Yuting, Wang Jianming","doi":"10.19852/j.cnki.jtcm.20240927.002","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To compare the efficacy and safety of different Traditional Chinese Medicine (TCM)-based kidney-tonifying and bone-strengthening therapies for rheumatoid arthritis (RA).</p><p><strong>Methods: </strong>The current Bayesian network Meta-analysis compared different TCM-based kidney-tonifying and bone-strengthening therapies for RA. Eight electronic databases and two trial registration platforms were searched. RevMan 5.4 and Stata 16 software were employed.</p><p><strong>Results: </strong>A total of 42 studies involving 3779 cases were included. The results showed that the most effective intervention for improving efficacy was Wanbi decoction; Bushen Quhan Zhiwang decoction was superior in reducing the incidence of adverse reactions; and Qiwei Tongbi oral liquid effectively reduced C-reactive protein and erythrocyte sedimentation rate levels.</p><p><strong>Conclusion: </strong>Combining TCMs with conventional Western Medicine can improve the clinical efficacy of RA treatments, reduce inflammatory indexes, and result in a higher safety profile. However, this conclusion needs to be verified by more high-quality randomized controlled trials.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"44 6","pages":"1067-1081"},"PeriodicalIF":0.0000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589564/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.19852/j.cnki.jtcm.20240927.002","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: To compare the efficacy and safety of different Traditional Chinese Medicine (TCM)-based kidney-tonifying and bone-strengthening therapies for rheumatoid arthritis (RA).
Methods: The current Bayesian network Meta-analysis compared different TCM-based kidney-tonifying and bone-strengthening therapies for RA. Eight electronic databases and two trial registration platforms were searched. RevMan 5.4 and Stata 16 software were employed.
Results: A total of 42 studies involving 3779 cases were included. The results showed that the most effective intervention for improving efficacy was Wanbi decoction; Bushen Quhan Zhiwang decoction was superior in reducing the incidence of adverse reactions; and Qiwei Tongbi oral liquid effectively reduced C-reactive protein and erythrocyte sedimentation rate levels.
Conclusion: Combining TCMs with conventional Western Medicine can improve the clinical efficacy of RA treatments, reduce inflammatory indexes, and result in a higher safety profile. However, this conclusion needs to be verified by more high-quality randomized controlled trials.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
