Mohamed Jameer Basha Jahankir, Harisharan Ramesh, Thilak Chakaravarthi, Ajay Agarwal, Amit Goyal and Gowri Manohari Balachander
{"title":"Strip electrodes: a novel, effective and minimally invasive therapeutic option for correcting DNS via electromechanical reshaping†","authors":"Mohamed Jameer Basha Jahankir, Harisharan Ramesh, Thilak Chakaravarthi, Ajay Agarwal, Amit Goyal and Gowri Manohari Balachander","doi":"10.1039/D4TB01306A","DOIUrl":null,"url":null,"abstract":"<p >Deviated nasal septum (DNS) is a common condition affecting nasal breathing, which is generally treated using septoplasty. However, this invasive surgical method carries potential risks of post-surgical complications. Alternatively, electromechanical reshaping (EMR) is a novel method that has evolved as a non-thermal, minimally invasive option to reshape the cartilage using mechanical pressure and direct current (DC) without significant tissue damage. However, the existing flat and needle electrodes tested in animal tissues have raised significant concerns due to their safety. Thus, herein, we aimed to develop a novel strip electrode configuration and optimize dosimetry to achieve efficient reshaping without compromising its safety. Electric field simulations showed that our novel 5-strip electrode configuration with a thickness of 0.5 mm achieved optimal electric field, requiring minimal current flow compared to flat electrodes. EMR was performed on <em>ex vivo</em> goat cartilage at various dosimetry groups to analyze four-day shape retention. The optimized strip electrode reshaped the <em>ex vivo</em> goat septal cartilage effectively at a dosimetry of 20 mA for 15 minutes, whereas the flat electrode needed 35 mA for 15 minutes. DMMB assay, ATR-FTIR spectroscopy, tensile testing, and histopathology analysis demonstrated reduced tissue damage while supporting increased efficiency and mechanical stability with the strip electrode configuration, emphasizing its safety. Thus, the optimized strip electrode-based EMR emerges as a viable non-invasive approach for reshaping the nasal septal cartilage, which can be used to treat DNS. Further <em>in vivo</em> studies are recommended to validate the long-term safety and efficacy of this technique.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 2","pages":" 668-682"},"PeriodicalIF":6.1000,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Materials Chemistry B","FirstCategoryId":"1","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2025/tb/d4tb01306a","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0
Abstract
Deviated nasal septum (DNS) is a common condition affecting nasal breathing, which is generally treated using septoplasty. However, this invasive surgical method carries potential risks of post-surgical complications. Alternatively, electromechanical reshaping (EMR) is a novel method that has evolved as a non-thermal, minimally invasive option to reshape the cartilage using mechanical pressure and direct current (DC) without significant tissue damage. However, the existing flat and needle electrodes tested in animal tissues have raised significant concerns due to their safety. Thus, herein, we aimed to develop a novel strip electrode configuration and optimize dosimetry to achieve efficient reshaping without compromising its safety. Electric field simulations showed that our novel 5-strip electrode configuration with a thickness of 0.5 mm achieved optimal electric field, requiring minimal current flow compared to flat electrodes. EMR was performed on ex vivo goat cartilage at various dosimetry groups to analyze four-day shape retention. The optimized strip electrode reshaped the ex vivo goat septal cartilage effectively at a dosimetry of 20 mA for 15 minutes, whereas the flat electrode needed 35 mA for 15 minutes. DMMB assay, ATR-FTIR spectroscopy, tensile testing, and histopathology analysis demonstrated reduced tissue damage while supporting increased efficiency and mechanical stability with the strip electrode configuration, emphasizing its safety. Thus, the optimized strip electrode-based EMR emerges as a viable non-invasive approach for reshaping the nasal septal cartilage, which can be used to treat DNS. Further in vivo studies are recommended to validate the long-term safety and efficacy of this technique.
期刊介绍:
Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive:
Antifouling coatings
Biocompatible materials
Bioelectronics
Bioimaging
Biomimetics
Biomineralisation
Bionics
Biosensors
Diagnostics
Drug delivery
Gene delivery
Immunobiology
Nanomedicine
Regenerative medicine & Tissue engineering
Scaffolds
Soft robotics
Stem cells
Therapeutic devices