Strip electrodes: a novel, effective and minimally invasive therapeutic option for correcting DNS via electromechanical reshaping†

IF 6.1 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS
Mohamed Jameer Basha Jahankir, Harisharan Ramesh, Thilak Chakaravarthi, Ajay Agarwal, Amit Goyal and Gowri Manohari Balachander
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Abstract

Deviated nasal septum (DNS) is a common condition affecting nasal breathing, which is generally treated using septoplasty. However, this invasive surgical method carries potential risks of post-surgical complications. Alternatively, electromechanical reshaping (EMR) is a novel method that has evolved as a non-thermal, minimally invasive option to reshape the cartilage using mechanical pressure and direct current (DC) without significant tissue damage. However, the existing flat and needle electrodes tested in animal tissues have raised significant concerns due to their safety. Thus, herein, we aimed to develop a novel strip electrode configuration and optimize dosimetry to achieve efficient reshaping without compromising its safety. Electric field simulations showed that our novel 5-strip electrode configuration with a thickness of 0.5 mm achieved optimal electric field, requiring minimal current flow compared to flat electrodes. EMR was performed on ex vivo goat cartilage at various dosimetry groups to analyze four-day shape retention. The optimized strip electrode reshaped the ex vivo goat septal cartilage effectively at a dosimetry of 20 mA for 15 minutes, whereas the flat electrode needed 35 mA for 15 minutes. DMMB assay, ATR-FTIR spectroscopy, tensile testing, and histopathology analysis demonstrated reduced tissue damage while supporting increased efficiency and mechanical stability with the strip electrode configuration, emphasizing its safety. Thus, the optimized strip electrode-based EMR emerges as a viable non-invasive approach for reshaping the nasal septal cartilage, which can be used to treat DNS. Further in vivo studies are recommended to validate the long-term safety and efficacy of this technique.

Abstract Image

带状电极:一种新颖,有效和微创的治疗选择,通过机电重塑纠正DNS。
鼻中隔偏曲(DNS)是影响鼻腔呼吸的常见疾病,通常采用鼻中隔成形术治疗。然而,这种侵入性手术方法存在术后并发症的潜在风险。另外,机电重塑(EMR)是一种新的方法,它已经发展成为一种非热的、微创的选择,利用机械压力和直流(DC)来重塑软骨,而不会造成明显的组织损伤。然而,现有的在动物组织中测试的平电极和针电极由于其安全性引起了极大的关注。因此,在此,我们的目标是开发一种新的带状电极配置和优化剂量法,以实现有效的重塑而不影响其安全性。电场模拟表明,与平面电极相比,我们的厚度为0.5 mm的新型5条电极配置获得了最佳电场,所需的电流最小。对不同剂量组山羊离体软骨进行EMR,分析4天形状保持情况。优化后的条形电极在20 mA的剂量下可以有效地重塑离体山羊鼻中隔软骨,而扁平电极则需要35 mA的剂量,持续15分钟。DMMB分析、ATR-FTIR光谱、拉伸测试和组织病理学分析表明,带状电极结构减少了组织损伤,同时支持提高效率和机械稳定性,强调了其安全性。因此,优化的条状电极EMR是一种可行的无创鼻中隔软骨重塑方法,可用于治疗鼻中隔软骨缺损。建议进一步的体内研究来验证该技术的长期安全性和有效性。
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来源期刊
Journal of Materials Chemistry B
Journal of Materials Chemistry B MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
11.50
自引率
4.30%
发文量
866
期刊介绍: Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive: Antifouling coatings Biocompatible materials Bioelectronics Bioimaging Biomimetics Biomineralisation Bionics Biosensors Diagnostics Drug delivery Gene delivery Immunobiology Nanomedicine Regenerative medicine & Tissue engineering Scaffolds Soft robotics Stem cells Therapeutic devices
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