{"title":"MnCO3–Au nanoparticles to enable catalytic tumor inhibition with immune activation†","authors":"Yingpei Yao, Zijie Lu, Yike Fu and Xiang Li","doi":"10.1039/D4TB02108H","DOIUrl":null,"url":null,"abstract":"<p >Catalytic nanomedicine, activated by endogenous stimuli to enable specific tumor inhibition, has attracted extensive interest in recent years. However, its therapeutic outcomes are often restrained by the weakly acidic microenvironment and limited H<small><sub>2</sub></small>O<small><sub>2</sub></small> endogenous content. Here, in this study, gold nanoparticles (AuNPs) with glucose oxidase-like activity are incorporated with biodegradable MnCO<small><sub>3</sub></small> nanoparticles. AuNPs catalyze glucose oxidation to generate gluconic acid and H<small><sub>2</sub></small>O<small><sub>2</sub></small>, while MnCO<small><sub>3</sub></small> is degraded by the generated gluconic acid as well as the acidic conditions in the tumor region to release Mn<small><sup>2+</sup></small> and HCO<small><sub>3</sub></small><small><sup>−</sup></small>. Then H<small><sub>2</sub></small>O<small><sub>2</sub></small> can be catalyzed by Mn<small><sup>2+</sup></small> and HCO<small><sub>3</sub></small><small><sup>−</sup></small> to produce reactive oxygen species (ROS). The effective production of on-site H<small><sub>2</sub></small>O<small><sub>2</sub></small> leads to promoted intracellular ROS and enhanced tumor inhibition. More importantly, the released Mn<small><sup>2+</sup></small> ions not only act as a catalytic agent, but also serve as a stimulator of the cGAS-STING pathway to activate anti-tumor immune responses. The <em>in vivo</em> study confirms that MnCO<small><sub>3</sub></small>–Au promotes T cell infiltration in tumors and exhibits a synergistic tumor suppression effect. This study may provide an alternative protocol for combinational tumor therapy utilizing the dual roles of Mn<small><sup>2+</sup></small> as an emerging catalytic agent as well as an immune agonist.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 2","pages":" 536-548"},"PeriodicalIF":6.1000,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Materials Chemistry B","FirstCategoryId":"1","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2025/tb/d4tb02108h","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0
Abstract
Catalytic nanomedicine, activated by endogenous stimuli to enable specific tumor inhibition, has attracted extensive interest in recent years. However, its therapeutic outcomes are often restrained by the weakly acidic microenvironment and limited H2O2 endogenous content. Here, in this study, gold nanoparticles (AuNPs) with glucose oxidase-like activity are incorporated with biodegradable MnCO3 nanoparticles. AuNPs catalyze glucose oxidation to generate gluconic acid and H2O2, while MnCO3 is degraded by the generated gluconic acid as well as the acidic conditions in the tumor region to release Mn2+ and HCO3−. Then H2O2 can be catalyzed by Mn2+ and HCO3− to produce reactive oxygen species (ROS). The effective production of on-site H2O2 leads to promoted intracellular ROS and enhanced tumor inhibition. More importantly, the released Mn2+ ions not only act as a catalytic agent, but also serve as a stimulator of the cGAS-STING pathway to activate anti-tumor immune responses. The in vivo study confirms that MnCO3–Au promotes T cell infiltration in tumors and exhibits a synergistic tumor suppression effect. This study may provide an alternative protocol for combinational tumor therapy utilizing the dual roles of Mn2+ as an emerging catalytic agent as well as an immune agonist.
期刊介绍:
Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive:
Antifouling coatings
Biocompatible materials
Bioelectronics
Bioimaging
Biomimetics
Biomineralisation
Bionics
Biosensors
Diagnostics
Drug delivery
Gene delivery
Immunobiology
Nanomedicine
Regenerative medicine & Tissue engineering
Scaffolds
Soft robotics
Stem cells
Therapeutic devices