MnCO3–Au nanoparticles to enable catalytic tumor inhibition with immune activation†

IF 6.1 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS
Yingpei Yao, Zijie Lu, Yike Fu and Xiang Li
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引用次数: 0

Abstract

Catalytic nanomedicine, activated by endogenous stimuli to enable specific tumor inhibition, has attracted extensive interest in recent years. However, its therapeutic outcomes are often restrained by the weakly acidic microenvironment and limited H2O2 endogenous content. Here, in this study, gold nanoparticles (AuNPs) with glucose oxidase-like activity are incorporated with biodegradable MnCO3 nanoparticles. AuNPs catalyze glucose oxidation to generate gluconic acid and H2O2, while MnCO3 is degraded by the generated gluconic acid as well as the acidic conditions in the tumor region to release Mn2+ and HCO3. Then H2O2 can be catalyzed by Mn2+ and HCO3 to produce reactive oxygen species (ROS). The effective production of on-site H2O2 leads to promoted intracellular ROS and enhanced tumor inhibition. More importantly, the released Mn2+ ions not only act as a catalytic agent, but also serve as a stimulator of the cGAS-STING pathway to activate anti-tumor immune responses. The in vivo study confirms that MnCO3–Au promotes T cell infiltration in tumors and exhibits a synergistic tumor suppression effect. This study may provide an alternative protocol for combinational tumor therapy utilizing the dual roles of Mn2+ as an emerging catalytic agent as well as an immune agonist.

Abstract Image

MnCO3-Au纳米颗粒通过免疫激活催化肿瘤抑制。
催化纳米药物,由内源性刺激激活,实现特异性肿瘤抑制,近年来引起了广泛的兴趣。然而,其治疗效果往往受到弱酸性微环境和H2O2内源性含量有限的制约。在这项研究中,具有葡萄糖氧化酶样活性的金纳米颗粒(AuNPs)与可生物降解的MnCO3纳米颗粒结合。AuNPs催化葡萄糖氧化生成葡萄糖酸和H2O2,而MnCO3被生成的葡萄糖酸和肿瘤区域的酸性条件降解,释放出Mn2+和HCO3-。然后H2O2可以被Mn2+和HCO3-催化生成活性氧(ROS)。现场H2O2的有效产生导致细胞内ROS的促进和肿瘤抑制的增强。更重要的是,释放的Mn2+离子不仅可以作为催化剂,还可以作为cGAS-STING通路的刺激物,激活抗肿瘤免疫反应。体内研究证实,MnCO3-Au促进肿瘤内T细胞浸润,具有协同抑瘤作用。这项研究可能为利用Mn2+作为新兴的催化剂和免疫激动剂的双重作用进行肿瘤联合治疗提供了一种替代方案。
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来源期刊
Journal of Materials Chemistry B
Journal of Materials Chemistry B MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
11.50
自引率
4.30%
发文量
866
期刊介绍: Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive: Antifouling coatings Biocompatible materials Bioelectronics Bioimaging Biomimetics Biomineralisation Bionics Biosensors Diagnostics Drug delivery Gene delivery Immunobiology Nanomedicine Regenerative medicine & Tissue engineering Scaffolds Soft robotics Stem cells Therapeutic devices
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