Photodynamic therapy for oral mucositis in cancer patients- a systematic review and meta-analysis

IF 3.1 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2024-12-01 DOI:10.1016/j.pdpdt.2024.104424

Betsy Joseph , Matti Mauramo , Baiju Kamalasanan Vijayakumary , Tuomas Waltimo , Sukumaran Anil , Timo Sorsa

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引用次数: 0

Abstract

Aim

This systematic review aimed to evaluate the efficacy of photodynamic therapy (PDT) in reducing the severity of chemotherapy-induced oral mucositis, and associated symptoms in cancer patients compared to standard care or other interventions.

Materials and methods

A comprehensive literature search identified seven relevant studies (randomized controlled trials and non-randomized clinical trials) published between January 1, 2000, and May 31, 2024. The data analysis was carried out using the standardized mean difference as the outcome measure. A random-effects model was fitted to the data. The rank correlation test and the regression test, using the standard error of the observed outcomes as predictors, were used to check for funnel plot asymmetry.

Results

Studies combining PDT with photobiomodulation therapy (PBMT) consistently showed superior therapeutic outcomes compared to PBMT alone, particularly in accelerating healing and reducing pain. In the meta-analysis (k = 4), the observed standardized mean differences ranged from -0.9605 to -0.0223, with most estimates being negative (100 %). The estimated average standardized mean difference based on the random-effects model was -0.5138 (95% CI: -0.8799 to -0.1477).

Conclusion

PDT, especially when combined with PBMT, shows promise in reducing the severity of oral mucositis and associated symptoms in cancer patients.

查看原文本刊更多论文

光动力疗法治疗癌症患者口腔黏膜炎-系统回顾和荟萃分析。

目的：本系统综述旨在评价光动力疗法（PDT）与标准治疗或其他干预措施相比，在降低化疗引起的口腔黏膜炎及相关症状的严重程度方面的疗效。材料和方法：对2000年1月1日至2024年5月31日期间发表的7项相关研究（随机对照试验和非随机临床试验）进行综合文献检索。数据分析采用标准化均差作为结果测量。对数据进行了随机效应模型拟合。采用秩相关检验和回归检验，以观察结果的标准误差为预测因子，检验漏斗图的不对称性。结果：与单独的PBMT相比，PDT联合光生物调节疗法（PBMT）的研究一致显示出更好的治疗效果，特别是在加速愈合和减轻疼痛方面。在meta分析（k=4）中，观察到的标准化平均差异范围为-0.9605至-0.0223，大多数估计值为负（100%）。基于随机效应模型的估计平均标准化平均差为[1] = -0.5138 （95% CI: -0.8799至-0.1477）。结论：PDT，特别是与PBMT联合使用，有望减轻癌症患者口腔黏膜炎的严重程度和相关症状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.