Evaluating fatigue and excessive daytime sleepiness: a comparative analysis of prevalence and correlating factors in interstitial lung disease patients and healthy controls.
Xiaoli Ouyang, Qinxue Shen, Shiting Zhou, Pei Zhou, Min Song, Ting Guo, Wei Guo, Yi Zhang, Hong Peng
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引用次数: 0
Abstract
Introduction: Fatigue and excessive daytime sleepiness (EDS) frequently affect interstitial lung disease (ILD) patients, while studies are limited. The study aims to determine the prevalence and contributing factors of fatigue and EDS in ILD patients.
Methods: This was a cross-sectional study. Consecutive patients diagnosed with ILD at the Second Xiangya Hospital of Central South University were recruited, and healthy volunteers were recruited as controls. Fatigue Assessment Scale and Epworth Sleepiness Scale scores were the basis for judging fatigue and EDS. The prevalence of fatigue and EDS between ILD patients and healthy volunteers were compared, and the differences in clinical characteristics between ILD patients with and without fatigue/EDS were analyzed. Binary logistic regression was used to analyze the correlation factors of fatigue and EDS.
Results: In this study, 92 healthy volunteers and 108 ILD patients were recruited. The prevalence of fatigue and EDS was higher in ILD patients than in healthy volunteers (40.7% vs 9.8%, 35.2% vs 14.1%). ILD patients with fatigue showed significantly worse pulmonary diffusion function and exercise tolerance, alongside reduced quality of life, and increased instances of EDS, anxiety, and depression. Patients with EDS were older than non-EDS patients (68.5 vs 61.5 years; p = 0.038) and had a higher prevalence of fatigue and depression, along with decreased quality of life. Multivariable logistic regression identified chest pain/oppression and diminished exercise capacity as factors linked to fatigue, and age over 60 years and diminished exercise capacity as factors associated with EDS.
Conclusion: ILD patients experience a higher prevalence and more severe impact of fatigue and EDS than healthy individuals, with associated factors including chest pain, diminished exercise capacity, and age. Pulmonary rehabilitation and evaluation and intervention of factors associated with fatigue and EDS such as pain, and diminished exercise capacity in ILD patients may help to improve the quality of life.
简介:疲劳和白天过度嗜睡(EDS)经常影响间质性肺疾病(ILD)患者,但研究有限。该研究旨在确定ILD患者疲劳和EDS的患病率及其影响因素。方法:采用横断面研究。招募在中南大学湘雅第二医院确诊为ILD的连续患者,并招募健康志愿者作为对照。疲劳评定量表和Epworth嗜睡量表评分是判断疲劳和EDS的依据。比较ILD患者与健康志愿者的疲劳和EDS患病率,并分析有无疲劳/EDS的ILD患者的临床特征差异。采用二元logistic回归分析疲劳与EDS的相关因素。结果:本研究招募了92名健康志愿者和108名ILD患者。ILD患者的疲劳和EDS患病率高于健康志愿者(40.7% vs 9.8%, 35.2% vs 14.1%)。伴有疲劳的ILD患者表现出明显较差的肺弥散功能和运动耐受性,同时生活质量下降,EDS、焦虑和抑郁发生率增加。EDS患者年龄大于非EDS患者(68.5岁vs 61.5岁;P = 0.038),疲劳和抑郁患病率较高,生活质量下降。多变量logistic回归发现,胸痛/压迫和运动能力下降是与疲劳相关的因素,60岁以上的年龄和运动能力下降是与EDS相关的因素。结论:与健康个体相比,ILD患者经历更高的患病率和更严重的疲劳和EDS影响,相关因素包括胸痛、运动能力下降和年龄。肺康复和评估和干预与疲劳和EDS相关的因素,如疼痛,ILD患者的运动能力下降可能有助于改善生活质量。