{"title":"First detection of NADC34-like porcine reproductive and respiratory syndrome virus strains in Japan.","authors":"Yoriko Yonezawa, Osamu Taira, Takashi Omori, Nobuyuki Tsutsumi, Katsuaki Sugiura","doi":"10.1292/jvms.24-0451","DOIUrl":null,"url":null,"abstract":"<p><p>Porcine reproductive and respiratory syndrome virus (PRRSV) is an important pathogen in the swine industry. We report for the first time the detection of NADC34-like PRRSV strains in Japan. Serum samples from 18 piglets in Okinawa Prefecture were analyzed for the open reading frame 5 (ORF5) gene encoding glycoprotein 5, which revealed that all samples belonged to sublineage 1.5 (L1A) of Lineage 1. Phylogenetic analysis, restriction fragment length polymorphism patterns, and glycosylation site characteristics confirmed the presence of NADC34-like strains that caused severe outbreaks in the U.S. and Asia. Despite its known pathogenicity, the farm showed only a transient increase in mortality. These findings highlight the need for further investigation into the pathogenicity of PRRSV strains and their potential for the emergence of new variants in Japan.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1000,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Veterinary Medical Science","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1292/jvms.24-0451","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Porcine reproductive and respiratory syndrome virus (PRRSV) is an important pathogen in the swine industry. We report for the first time the detection of NADC34-like PRRSV strains in Japan. Serum samples from 18 piglets in Okinawa Prefecture were analyzed for the open reading frame 5 (ORF5) gene encoding glycoprotein 5, which revealed that all samples belonged to sublineage 1.5 (L1A) of Lineage 1. Phylogenetic analysis, restriction fragment length polymorphism patterns, and glycosylation site characteristics confirmed the presence of NADC34-like strains that caused severe outbreaks in the U.S. and Asia. Despite its known pathogenicity, the farm showed only a transient increase in mortality. These findings highlight the need for further investigation into the pathogenicity of PRRSV strains and their potential for the emergence of new variants in Japan.
期刊介绍：
JVMS is a peer-reviewed journal and publishes a variety of papers on veterinary science from basic research to applied science and clinical research. JVMS is published monthly and consists of twelve issues per year. Papers are from the areas of anatomy, physiology, pharmacology, toxicology, pathology, immunology, microbiology, virology, parasitology, internal medicine, surgery, clinical pathology, theriogenology, avian disease, public health, ethology, and laboratory animal science. Although JVMS has played a role in publishing the scientific achievements of Japanese researchers and clinicians for many years, it now also accepts papers submitted from all over the world.
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