Association between frailty and adverse outcomes after cardiac resynchronization therapy: a systematic review and meta-analysis.

IF 3.5 3区 医学 Q2 GERIATRICS & GERONTOLOGY
European Geriatric Medicine Pub Date : 2025-02-01 Epub Date: 2024-12-04 DOI:10.1007/s41999-024-01112-9
Xiaowang Li, Fei Fang
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引用次数: 0

Abstract

Aim: To synthesize evidence, using data from published studies, on the association of frailty with the outcomes after cardiac resynchronization therapy (CRT).

Methods: The systematic search of PubMed, Web of Science, Scopus, and Embase databases was done to identify observational studies (cohort/case-control/cross-sectional) that used an objective method for frailty assessment and had presented adjusted effect sizes. STATA version 15.0 was used to conduct analysis, which was based on random effects model.

Results: Fifteen studies were included. Frailty was found to be associated with an increased risk of in-hospital mortality (odds ratio (OR) 6.96, 95% confidence interval (CI) 5.48, 8.85). The effect of frailty on the response to CRT was not statistically significant (OR 0.55, 95% CI 0.19, 1.59). The pooled effect size indicated that frailty was associated with somewhat bigger but not statistically significant increase in the risk of complications (OR 1.70, 95% CI 0.93, 3.12). The risks of mortality and decompensated heart failure on long-term follow up were higher in frail patients (Hazard ratio (HR) 1.75, 95% CI 1.40, 2.17 and HR 3.03, 95% CI 1.33, 6.90, respectively) compared to patients without frailty. The risk of readmission was higher in frail patients, however, it did not achieve statistical significance (HR 2.63, 95% CI 0.89, 7.75).

Conclusion: Frail CRT patients could be at higher risks of mortality, decompensated heart failure, and may have potentially higher rates of complications. Integrating frailty assessment into pre-CRT evaluation and customizing interventions for frail patients might be an essential steps towards enhancing outcomes in this population.

心脏再同步化治疗后虚弱和不良后果之间的关系:系统回顾和荟萃分析。
目的:利用已发表的研究数据,综合虚弱与心脏再同步化治疗(CRT)后结果的关联的证据。方法:系统检索PubMed、Web of Science、Scopus和Embase数据库,以确定使用客观方法进行脆弱性评估并提出调整效应量的观察性研究(队列/病例对照/横断面)。采用STATA 15.0版本进行分析,采用随机效应模型。结果:纳入15项研究。虚弱被发现与院内死亡风险增加相关(优势比(OR) 6.96, 95%可信区间(CI) 5.48, 8.85)。虚弱对CRT疗效的影响无统计学意义(OR 0.55, 95% CI 0.19, 1.59)。合并效应大小表明,虚弱与并发症风险增加相关,但没有统计学意义(OR 1.70, 95% CI 0.93, 3.12)。在长期随访中,体弱患者的死亡率和失代偿性心力衰竭的风险高于非体弱患者(风险比分别为1.75,95% CI 1.40, 2.17和HR 3.03, 95% CI 1.33, 6.90)。体弱患者再入院风险较高,但无统计学意义(HR 2.63, 95% CI 0.89, 7.75)。结论:虚弱的CRT患者可能有更高的死亡率、失代偿性心力衰竭的风险,并可能有更高的并发症发生率。将虚弱评估纳入crt前评估并为虚弱患者定制干预措施可能是提高这一人群预后的重要步骤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
European Geriatric Medicine
European Geriatric Medicine GERIATRICS & GERONTOLOGY-
CiteScore
6.70
自引率
2.60%
发文量
114
审稿时长
6-12 weeks
期刊介绍: European Geriatric Medicine is the official journal of the European Geriatric Medicine Society (EUGMS). Launched in 2010, this journal aims to publish the highest quality material, both scientific and clinical, on all aspects of Geriatric Medicine. The EUGMS is interested in the promotion of Geriatric Medicine in any setting (acute or subacute care, rehabilitation, nursing homes, primary care, fall clinics, ambulatory assessment, dementia clinics..), and also in functionality in old age, comprehensive geriatric assessment, geriatric syndromes, geriatric education, old age psychiatry, models of geriatric care in health services, and quality assurance.
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