Neuronavigated Focalized Transcranial Direct Current Stimulation Administered During Functional Magnetic Resonance Imaging.

IF 1.2 4区 综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES
Filip Niemann, Alireza Shahbabaie, Sven Paßmann, Steffen Riemann, Robert Malinowski, Harun Kocataş, Leonardo M Caisachana Guevara, Mohamed Abdelmotaleb, Daria Antonenko, Felix Blankenburg, Rico Fischer, Gesa Hartwigsen, Shu-Chen Li, Michael A Nitsche, Axel Thielscher, Dagmar Timmann, Anna Fromm, Dayana Hayek, Ann-Kathrin Hubert, Andrew K Martin, Alexander Hunold, Agnes Flöel, Marcus Meinzer
{"title":"Neuronavigated Focalized Transcranial Direct Current Stimulation Administered During Functional Magnetic Resonance Imaging.","authors":"Filip Niemann, Alireza Shahbabaie, Sven Paßmann, Steffen Riemann, Robert Malinowski, Harun Kocataş, Leonardo M Caisachana Guevara, Mohamed Abdelmotaleb, Daria Antonenko, Felix Blankenburg, Rico Fischer, Gesa Hartwigsen, Shu-Chen Li, Michael A Nitsche, Axel Thielscher, Dagmar Timmann, Anna Fromm, Dayana Hayek, Ann-Kathrin Hubert, Andrew K Martin, Alexander Hunold, Agnes Flöel, Marcus Meinzer","doi":"10.3791/67155","DOIUrl":null,"url":null,"abstract":"<p><p>Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique that allows the modulation of the excitability and plasticity of the human brain. Focalized tDCS setups use specific electrode arrangements to constrain the current flow to circumscribed brain regions. However, the effectiveness of focalized tDCS can be compromised by electrode positioning errors on the scalp, resulting in significant reductions of the current dose reaching the target brain regions for tDCS. Electrode placement guided by neuronavigation based on the individual's head and brain anatomy derived from structural magnetic resonance imaging (MRI) data may be suited to improve positioning accuracy. This protocol describes the method of neuronavigated electrode placement for a focalized tDCS setup, which is suitable for concurrent administration during functional MRI (fMRI). We also quantify the accuracy of electrode placement and investigate electrode drift in a concurrent tDCS-fMRI experiment. Critical steps involve the optimization of electrode positions based on current modeling that considers the individual's head and brain anatomy, the implementation of neuronavigated electrode placement on the scalp, and the administration of optimized and focal tDCS during fMRI. The regional precision of electrode placement is quantified using the Euclidean norm (L<sup>2 </sup>Norm) to determine deviations of the actual from the intended electrode positions during a concurrent tDCS-fMRI study. Any potential displacement of electrodes (drift) during the experiment is investigated by comparing actual electrode positions before and after the fMRI acquisition. In addition, we directly compare the placement accuracy of neuronavigated tDCS to that achieved by a scalp-based targeting approach (a 10-20 Electroencephalography (EEG) system). These analyses demonstrate superior placement accuracy for neuronavigation compared to scalp-based electrode placement and negligible electrode drift across a 20 min scanning period.</p>","PeriodicalId":48787,"journal":{"name":"Jove-Journal of Visualized Experiments","volume":" 213","pages":""},"PeriodicalIF":1.2000,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Jove-Journal of Visualized Experiments","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.3791/67155","RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique that allows the modulation of the excitability and plasticity of the human brain. Focalized tDCS setups use specific electrode arrangements to constrain the current flow to circumscribed brain regions. However, the effectiveness of focalized tDCS can be compromised by electrode positioning errors on the scalp, resulting in significant reductions of the current dose reaching the target brain regions for tDCS. Electrode placement guided by neuronavigation based on the individual's head and brain anatomy derived from structural magnetic resonance imaging (MRI) data may be suited to improve positioning accuracy. This protocol describes the method of neuronavigated electrode placement for a focalized tDCS setup, which is suitable for concurrent administration during functional MRI (fMRI). We also quantify the accuracy of electrode placement and investigate electrode drift in a concurrent tDCS-fMRI experiment. Critical steps involve the optimization of electrode positions based on current modeling that considers the individual's head and brain anatomy, the implementation of neuronavigated electrode placement on the scalp, and the administration of optimized and focal tDCS during fMRI. The regional precision of electrode placement is quantified using the Euclidean norm (LNorm) to determine deviations of the actual from the intended electrode positions during a concurrent tDCS-fMRI study. Any potential displacement of electrodes (drift) during the experiment is investigated by comparing actual electrode positions before and after the fMRI acquisition. In addition, we directly compare the placement accuracy of neuronavigated tDCS to that achieved by a scalp-based targeting approach (a 10-20 Electroencephalography (EEG) system). These analyses demonstrate superior placement accuracy for neuronavigation compared to scalp-based electrode placement and negligible electrode drift across a 20 min scanning period.

在功能磁共振成像期间给予神经导航聚焦经颅直流电刺激。
经颅直流电刺激(tDCS)是一种非侵入性的脑刺激技术,可以调节人脑的兴奋性和可塑性。集中tDCS装置使用特定的电极安排来限制电流流向限定的大脑区域。然而,定向tDCS的有效性可能会受到头皮上电极定位错误的影响,导致tDCS到达目标脑区的电流剂量显著减少。基于个体头部和大脑结构磁共振成像(MRI)数据的神经导航引导下的电极放置可能适合于提高定位精度。本方案描述了神经导航电极放置的方法,用于聚焦tDCS设置,适用于功能MRI (fMRI)期间的并发给药。我们还量化了电极放置的准确性,并在并发tDCS-fMRI实验中研究了电极漂移。关键步骤包括基于当前模型的电极位置的优化,该模型考虑了个体的头部和大脑解剖结构,在头皮上实现神经导航电极放置,以及在fMRI期间优化和局灶tDCS的管理。使用欧几里得范数(L2范数)量化电极放置的区域精度,以确定并发tDCS-fMRI研究期间实际与预期电极位置的偏差。通过比较fMRI采集前后的实际电极位置,研究实验过程中电极的任何潜在位移(漂移)。此外,我们直接比较了神经导航tDCS与基于头皮的定位方法(10-20脑电图(EEG)系统)的定位精度。这些分析表明,与基于头皮的电极放置相比,神经导航的放置精度更高,并且在20分钟的扫描周期内电极漂移可以忽略不计。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Jove-Journal of Visualized Experiments
Jove-Journal of Visualized Experiments MULTIDISCIPLINARY SCIENCES-
CiteScore
2.10
自引率
0.00%
发文量
992
期刊介绍: JoVE, the Journal of Visualized Experiments, is the world''s first peer reviewed scientific video journal. Established in 2006, JoVE is devoted to publishing scientific research in a visual format to help researchers overcome two of the biggest challenges facing the scientific research community today; poor reproducibility and the time and labor intensive nature of learning new experimental techniques.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信