{"title":"Prevalence and antibiotic resistance of Staphylococcus aureus in wound infections: a hospital study in Hawassa, Ethiopia.","authors":"Biruktawit Sahle, Yared Merid","doi":"10.3855/jidc.19023","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Wound infections are common nosocomial infections associated with increased morbidity and mortality. Staphylococcus aureus, particularly methicillin-resistant S. aureus (MRSA), is a major cause of hospital-acquired wound infections. This study aimed to determine the burden and antimicrobial susceptibility pattern of S. aureus and MRSA, among patients with wound infections at Hawassa University Comprehensive Specialized Hospital (HUCSH), Hawassa, Ethiopia.</p><p><strong>Methodology: </strong>A hospital-based cross-sectional study was conducted on 246 admitted patients with wound infections at HUCSH from April to August 2021. Wound swabs were aseptically collected and cultured for bacterial isolation and drug susceptibility testing. Data were analyzed using SPSS version 20, and descriptive statistics were computed.</p><p><strong>Results: </strong>Among the 246 clinical specimens analyzed, S. aureus was isolated from 57 (23.2%), of which 5 (8.8%) were identified as MRSA. All S. aureus strains were sensitive to linezolid. The highest resistance was observed for penicillin (52 strains, 91.2%), and 24.6% of S. aureus strains were found to be multidrug resistant. All MRSA strains were isolated from patients with no history of past wound infection, and all of them were sensitive to vancomycin.</p><p><strong>Conclusions: </strong>This study identified S. aureus (23.2%) and MRSA (8.8%) along with their antimicrobial resistance among patients with wound infections at HUCSH. A substantial proportion (24.6%) of S. aureus exhibited multidrug resistance. However, all MRSA isolates were sensitive to vancomycin. Continuous drug resistance monitoring (drug surveillance) is crucial to manage and prevent resistance spread in the hospital.</p>","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"18 10","pages":"1530-1538"},"PeriodicalIF":1.4000,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Infection in Developing Countries","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3855/jidc.19023","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Wound infections are common nosocomial infections associated with increased morbidity and mortality. Staphylococcus aureus, particularly methicillin-resistant S. aureus (MRSA), is a major cause of hospital-acquired wound infections. This study aimed to determine the burden and antimicrobial susceptibility pattern of S. aureus and MRSA, among patients with wound infections at Hawassa University Comprehensive Specialized Hospital (HUCSH), Hawassa, Ethiopia.
Methodology: A hospital-based cross-sectional study was conducted on 246 admitted patients with wound infections at HUCSH from April to August 2021. Wound swabs were aseptically collected and cultured for bacterial isolation and drug susceptibility testing. Data were analyzed using SPSS version 20, and descriptive statistics were computed.
Results: Among the 246 clinical specimens analyzed, S. aureus was isolated from 57 (23.2%), of which 5 (8.8%) were identified as MRSA. All S. aureus strains were sensitive to linezolid. The highest resistance was observed for penicillin (52 strains, 91.2%), and 24.6% of S. aureus strains were found to be multidrug resistant. All MRSA strains were isolated from patients with no history of past wound infection, and all of them were sensitive to vancomycin.
Conclusions: This study identified S. aureus (23.2%) and MRSA (8.8%) along with their antimicrobial resistance among patients with wound infections at HUCSH. A substantial proportion (24.6%) of S. aureus exhibited multidrug resistance. However, all MRSA isolates were sensitive to vancomycin. Continuous drug resistance monitoring (drug surveillance) is crucial to manage and prevent resistance spread in the hospital.
简介：伤口感染是常见的医院感染，与发病率和死亡率增加有关。金黄色葡萄球菌，特别是耐甲氧西林金黄色葡萄球菌（MRSA），是医院获得性伤口感染的主要原因。本研究旨在确定埃塞俄比亚阿瓦萨大学综合专科医院（HUCSH）伤口感染患者的金黄色葡萄球菌和MRSA的负担和抗菌药物敏感性模式。方法：对2021年4月至8月在hush住院的246例伤口感染患者进行了以医院为基础的横断面研究。无菌收集创面拭子进行细菌分离培养和药敏试验。数据采用SPSS version 20进行分析，并进行描述性统计。结果：246份临床标本中，分离到金黄色葡萄球菌57份（23.2%），其中鉴定为MRSA 5份（8.8%）。所有金黄色葡萄球菌菌株对利奈唑胺均敏感。其中以青霉素耐药最高（52株，占91.2%），耐多药金黄色葡萄球菌占24.6%。所有MRSA菌株均来自无伤口感染史的患者，且均对万古霉素敏感。结论：本研究在hush医院伤口感染患者中鉴定出金黄色葡萄球菌（23.2%）和MRSA（8.8%）及其抗菌药物耐药性。相当比例的金黄色葡萄球菌（24.6%）表现出多药耐药。所有MRSA分离株均对万古霉素敏感。持续的耐药监测（药物监测）对于管理和防止耐药在医院传播至关重要。
期刊介绍：
The Journal of Infection in Developing Countries (JIDC) is an international journal, intended for the publication of scientific articles from Developing Countries by scientists from Developing Countries.
JIDC is an independent, on-line publication with an international editorial board. JIDC is open access with no cost to view or download articles and reasonable cost for publication of research artcles, making JIDC easily availiable to scientists from resource restricted regions.
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