A clinical and hematologic approach to basophilia in dogs, cats, and horses.

IF 1.2 4区 农林科学 Q3 VETERINARY SCIENCES
Alex Mau, S M Keller, Amir Kol
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引用次数: 0

Abstract

Background: Basophils are the rarest blood leukocyte in most healthy domestic mammals and the clinical significance of basophilia is poorly understood.

Objectives: To empirically determine magnitude thresholds for basophilia, identify its hematologic correlates, and identify associations between breeds, specific diseases, disease categories, organ systems, and basophilia in dogs, cats, and horses.

Methods: CBCs and clinical information from dogs, cats, and horses were collected from the University of California-Davis School of Veterinary Medicine between 2000 and 2020. Relationships between basophil concentration and other CBC parameters were evaluated by computing Pearson's correlation (r). Magnitude thresholds for basophilia (ie, mild, moderate, severe) were determined by evaluating the distribution of basophil counts for each species. For severe cases of basophilia, the clinical diagnoses were categorized by the organ system affected and the underlying pathomechanism. Basophilia groups were compared to a time-matched, randomly selected control group, and chi-square analyses were performed to evaluate associations with disease.

Results: A total of 143 841 (dog), 32 576 (cat), and 44 887 (horse) CBCs were collected. For all three species, basophilia was over-represented in some breeds. Basophilia was associated with respiratory disease in both dogs and cats. In dogs, lymphoma and mast cell neoplasia were associated with basophilia. In horses, an increased incidence of basophilia was not associated with any disease category or organ system.

Conclusions: This is the largest study evaluating the hematologic correlations and disease associations with basophilia in dogs, cats, and horses. While basophilia was reported alongside many diseases, certain associations may aid clinicians in narrowing down underlying causes.

狗、猫和马嗜碱性的临床和血液学方法。
背景:嗜碱性细胞是大多数健康家养哺乳动物中最罕见的血液白细胞,嗜碱性细胞的临床意义尚不清楚。目的:以经验确定嗜碱性的大小阈值,确定其血液学相关性,并确定犬、猫和马的品种、特定疾病、疾病类别、器官系统和嗜碱性之间的关联。方法:收集2000 - 2020年加州大学戴维斯分校兽医学院犬、猫和马的CBCs和临床信息。通过计算Pearson’s correlation (r)来评估嗜碱性细胞浓度与其他CBC参数之间的关系。通过评估每个物种的嗜碱性细胞计数分布来确定嗜碱性细胞的大小阈值(即轻度、中度、重度)。对于重度嗜碱性粒细胞增多症,临床诊断依据受累的器官系统和潜在的病理机制进行分类。将嗜碱性粒细胞组与时间匹配的随机选择的对照组进行比较,并进行卡方分析以评估与疾病的关联。结果:共采集犬143841条、猫32576条、马44887条CBCs。在所有三个品种中,嗜碱性在某些品种中被过度代表。嗜碱性与狗和猫的呼吸系统疾病有关。在狗中,淋巴瘤和肥大细胞瘤与嗜碱性相关。在马中,嗜碱性粒细胞增多与任何疾病类别或器官系统无关。结论:这是评估狗、猫和马血液学相关性和疾病与嗜碱性细胞病相关性的最大研究。虽然嗜碱性粒细胞增多症与许多疾病一起报道,但某些关联可能有助于临床医生缩小潜在原因。
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来源期刊
Veterinary clinical pathology
Veterinary clinical pathology 农林科学-兽医学
CiteScore
1.70
自引率
16.70%
发文量
133
审稿时长
18-36 weeks
期刊介绍: Veterinary Clinical Pathology is the official journal of the American Society for Veterinary Clinical Pathology (ASVCP) and the European Society of Veterinary Clinical Pathology (ESVCP). The journal''s mission is to provide an international forum for communication and discussion of scientific investigations and new developments that advance the art and science of laboratory diagnosis in animals. Veterinary Clinical Pathology welcomes original experimental research and clinical contributions involving domestic, laboratory, avian, and wildlife species in the areas of hematology, hemostasis, immunopathology, clinical chemistry, cytopathology, surgical pathology, toxicology, endocrinology, laboratory and analytical techniques, instrumentation, quality assurance, and clinical pathology education.
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