Significance of the modified global leadership initiative on malnutrition (GLIM) criteria malcondition for patients with biliary tract cancer.

IF 1.7 4区医学 Q2 SURGERY

Surgery Today Pub Date : 2025-06-01 Epub Date: 2024-12-02 DOI:10.1007/s00595-024-02970-3

Takamichi Igarashi, Norifumi Harimoto, Ryosuke Fukushima, Kei Hagiwara, Kouki Hoshino, Shunsuke Kawai, Norihiro Ishii, Mariko Tsukagoshi, Kenichiro Araki, Ken Shirabe

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引用次数: 0

Abstract

Purpose: This study investigated the significance of the Global Leadership Initiative on Malnutrition (GLIM) for patients with resected biliary tract cancers.

Methods: The subjects of this retrospective analysis were 114 patients who underwent radical surgery for cholangiocarcinoma between 2018 and 2023. We analyzed both handgrip force and skeletal muscle area and classified patients as having GLIM malnutrition or modified GLIM malcondition. We also evaluated clinicopathological factors, short-term outcomes, and prognoses.

Results: The GLIM criteria identified 47 patients (41.2%) with malnutrition and 13 patients (11.4%) with modified GLIM malcondition. Overall survival (P = 0.009) and recurrence-free survival (P = 0.016) were significantly different between the well-nourished and malnourished patients according to the GLIM criteria. Furthermore, modified GLIM criteria malcondition was a significant prognostic factor for both recurrence-free and overall survival (P = 0.002 and P < 0.001, respectively). Multivariate analysis identified a higher carcinoembryonic antigen level and modified GLIM malcondition as predictors of overall and recurrence-free survival. Pathological stage ≥ III was also a predictor of recurrence-free survival. On comparing the prognoses of modified GLIM malcondition and GLIM malnutrition using the Akaike Information Criteria, the modified GLIM malcondition was identified as a stronger prognostic factor.

Conclusion: A modified GLIM malcondition can be a highly useful prognostic marker for patients with resected biliary tract cancer.

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修订的全球营养不良领导倡议（GLIM）标准对胆道癌患者的意义。

目的：本研究探讨全球营养不良领导倡议（GLIM）对胆道肿瘤切除术患者的意义。方法：回顾性分析2018年至2023年间接受胆管癌根治性手术的114例患者。我们分析了握力和骨骼肌面积，并将患者分为GLIM营养不良或改进型GLIM不良。我们还评估了临床病理因素、短期结果和预后。结果：GLIM标准确定了47例（41.2%）营养不良患者和13例（11.4%）改良GLIM不良患者。根据GLIM标准，营养良好和营养不良患者的总生存率（P = 0.009）和无复发生存率（P = 0.016）差异有统计学意义。此外，改良的GLIM标准不良是无复发和总生存的重要预后因素（P = 0.002和P）。结论：改良的GLIM不良可作为胆道癌切除术患者预后的重要指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Surgery Today 医学-外科

CiteScore

4.90

自引率

4.00%

发文量

208

审稿时长

1 months

期刊介绍： Surgery Today is the official journal of the Japan Surgical Society. The main purpose of the journal is to provide a place for the publication of high-quality papers documenting recent advances and new developments in all fields of surgery, both clinical and experimental. The journal welcomes original papers, review articles, and short communications, as well as short technical reports("How to do it"). The "How to do it" section will includes short articles on methods or techniques recommended for practical surgery. Papers submitted to the journal are reviewed by an international editorial board. Field of interest: All fields of surgery.