Exercise during pregnancy modulates infant cellular and whole-body adiposity.

IF 2.2 Q3 PHYSIOLOGY

Physiological Reports Pub Date : 2024-12-01 DOI:10.14814/phy2.70145

Alex Claiborne, Filip Jevtovic, Donghai Zheng, Cody Strom, Breanna Wisseman, Samantha McDonald, Edward Newton, Steven Mouro, James DeVente, Joseph A Houmard, Nicholas T Broskey, Linda E May

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Abstract

Non-pharmaceutical interventions are needed to target the growing intergenerational cycle of obesity. We aimed to determine whether in utero exposure to different exercise doses during pregnancy directly reduces infant cellular and whole-body adiposity. Pregnant women completed ~24 weeks of supervised exercise training; for standardization of exercise analysis (frequency, intensity, time, and volume-FIT-V), metrics were assessed from 16 to 36 weeks. Mesenchymal stem cells (MSC) collected from the umbilical cord at delivery underwent 21 days of adipogenic differentiation, then Oil Red O staining for lipid content. Infant body composition was measured at 1 month of age. ANCOVA and Pearson correlations determined the influence of prenatal exercise on infant adiposity. Exercise decreased infant MSC lipid content (p = 0.01) and body fat percentage (p = 0.009) irrespective of dose. Total exercise volume throughout pregnancy was negatively correlated with infant body fat % (R² = 0.31, p = 0.02) due to lower subscapular skinfolds (R² = 0.30, p = 0.02), while weekly exercise duration influenced adipogenic MSC lipid accumulation (R² = -0.23, p = 0.03) and BF% (R² = -0.15, p = 0.01). In utero exposure to exercise reduced cellular and whole-body infant adiposity in a dose-dependent manner.

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怀孕期间的运动调节婴儿细胞和全身肥胖。

非药物干预措施需要针对日益增长的代际肥胖循环。我们的目的是确定在怀孕期间在子宫内暴露于不同的运动剂量是否直接减少婴儿细胞和全身肥胖。孕妇完成~24周的有监督的运动训练；为了标准化运动分析（频率、强度、时间和体积- fit - v），从16周到36周对指标进行评估。将分娩时采集的脐带间充质干细胞（MSC）进行21天的成脂分化，然后进行油红O染色检测脂质含量。在1月龄时测定婴儿体成分。ANCOVA和Pearson相关性确定了产前运动对婴儿肥胖的影响。无论剂量如何，运动均可降低婴儿间充质干细胞脂含量（p = 0.01）和体脂率（p = 0.009）。妊娠期总运动量与婴儿体脂率（R2 = 0.31, p = 0.02）呈负相关（R2 = 0.30, p = 0.02），原因是肩胛下皮褶较低（R2 = 0.30, p = 0.02），而每周运动时间影响脂肪源性间充质干细胞脂质积累（R2 = -0.23, p = 0.03）和BF% （R2 = -0.15, p = 0.01）。在子宫内暴露于运动以剂量依赖的方式减少细胞和全身婴儿肥胖。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Physiological Reports PHYSIOLOGY-

CiteScore

4.20

自引率

4.00%

发文量

374

审稿时长

9 weeks

期刊介绍： Physiological Reports is an online only, open access journal that will publish peer reviewed research across all areas of basic, translational, and clinical physiology and allied disciplines. Physiological Reports is a collaboration between The Physiological Society and the American Physiological Society, and is therefore in a unique position to serve the international physiology community through quick time to publication while upholding a quality standard of sound research that constitutes a useful contribution to the field.