Impact of the International Tumor Budding Consensus Conference Recommendations in Oral Cancer.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2024-12-01 DOI:10.1111/odi.15215

Katerina Kopecka, Michal Herman, Jaroslav Michalek, Jana Zapletalova, Marketa Hermanova, Priska Liptakova, Michal Hendrych, Michal Mozola, Richard Pink

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引用次数: 0

Abstract

Objectives: Tumor budding was suggested as a valuable prognostic factor in oral squamous cell carcinoma (OSCC) but lacks a standardized scoring system. This study evaluates tumor budding in OSCC using the scoring system recommended by the International Tumor Budding Consensus Conference (ITBCC) 2016.

Materials and methods: The study included 114 patients with resected OSCC. Tumor budding was evaluated according to ITBCC criteria and assigned to three categories (low, intermediate, and high tumor budding). The associations between tumor budding and clinicopathological parameters were examined and survival rate analyses were performed by the Kaplan-Meier method. The prognostic value of tumor budding was assessed by Cox regression analysis.

Results: Significant correlations of tumor budding with clinicopathological parameters including lymph node metastasis, grade, stage, perineural and lymphovascular invasion, and local recurrence were found. Intermediate and high tumor budding were significantly and independently associated with worse disease-free survival. High tumor budding was identified as an independent prognostic factor for disease-specific and overall survival.

Conclusions: The ITBCC scoring system represents a simple, feasible, and reproducible method to evaluate tumor budding in OSCC. Tumor budding, according to ITBCC criteria, showed its prognostic value in resected OSCC, and its incorporation into the histopathological reporting guidelines should be considered.

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国际肿瘤萌芽共识会议建议对口腔癌的影响。

目的：肿瘤出芽被认为是口腔鳞状细胞癌（OSCC）的一个有价值的预后因素，但缺乏标准化的评分系统。本研究使用2016年国际肿瘤出芽共识会议（ITBCC）推荐的评分系统评估OSCC的肿瘤出芽。材料和方法：本研究纳入114例OSCC切除术患者。根据ITBCC标准评估肿瘤出芽，并将其分为低、中、高肿瘤出芽三类。检查肿瘤出芽与临床病理参数之间的关系，并通过Kaplan-Meier方法进行生存率分析。采用Cox回归分析评估肿瘤出芽的预后价值。结果：肿瘤出芽与淋巴结转移、分级、分期、周围神经及淋巴血管浸润、局部复发等临床病理参数有显著相关性。中度和高度肿瘤出芽与较差的无病生存显著且独立相关。高肿瘤出芽被确定为疾病特异性和总体生存的独立预后因素。结论：ITBCC评分系统是一种简单、可行、可重复的评价OSCC肿瘤出芽的方法。根据ITBCC标准，肿瘤出芽在切除的OSCC中显示其预后价值，应考虑将其纳入组织病理学报告指南。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.