{"title":"Disturbed neurovascular coupling in patients with white matter hyperintensities: potential biomarker for cognitive impairment.","authors":"Hui Li, Chao Chai, Yuanliang Xie, Huiying Wang, Xuedong Bai, You Li, Qin Zhong, Mingze Xu, Xiang Wang, Shuang Xia","doi":"10.1007/s00234-024-03459-z","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To explore the neurovascular mechanisms of white matter hyperintensities (WMHs)-related cognitive impairment by introducing a neurovascular biomarker, neurovascular coupling (NVC).</p><p><strong>Methods: </strong>We applied resting-state functional magnetic resonance imaging combined with arterial spin labeling to investigate the NVC dysfunctional patterns in patients with pure WMHs. Partial correlation, mediation, and exploratory subgroup analyses were adopted to explore the relationship among WMHs, NVC dysfunction, and cognitive decline.</p><p><strong>Results: </strong>We found 21 brain regions with NVC dysfunction in patients with pure WMHs, mainly distributed in the default mode network, dorsal attention network, subcortical nucleus, and limbic system (p < 0.0125, Bonferroni correction). The NVC dysfunction of brain regions in the subcortical nucleus and limbic system correlated with the total WMHs burden and paraventricular WMHs burden (q < 0.05, FDR correction). The reduced NVC of the left amygdala partially mediated the impact of paraventricular WMHs on executive function (Mediation effect: -0.117; 95%CI: -4.042,-0.011; p < 0.05). Among the WMHs subjects without cognitive impairment, the increased NVC of the left basal ganglia significantly correlated with the MoCA score (r = 0.539, p < 0.05).</p><p><strong>Conclusion: </strong>These findings reveal an underlying neurovascular mechanism of WMHs-related cognitive impairment. The neurovascular functions of the left amygdala and left basal ganglia may involve cognitive damage and compensation, respectively, and can be used as potential biomarkers and therapeutic targets for cognitive impairment in patients with WMHs.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":"66 11","pages":"1967-1978"},"PeriodicalIF":2.4000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroradiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00234-024-03459-z","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/1 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose: To explore the neurovascular mechanisms of white matter hyperintensities (WMHs)-related cognitive impairment by introducing a neurovascular biomarker, neurovascular coupling (NVC).
Methods: We applied resting-state functional magnetic resonance imaging combined with arterial spin labeling to investigate the NVC dysfunctional patterns in patients with pure WMHs. Partial correlation, mediation, and exploratory subgroup analyses were adopted to explore the relationship among WMHs, NVC dysfunction, and cognitive decline.
Results: We found 21 brain regions with NVC dysfunction in patients with pure WMHs, mainly distributed in the default mode network, dorsal attention network, subcortical nucleus, and limbic system (p < 0.0125, Bonferroni correction). The NVC dysfunction of brain regions in the subcortical nucleus and limbic system correlated with the total WMHs burden and paraventricular WMHs burden (q < 0.05, FDR correction). The reduced NVC of the left amygdala partially mediated the impact of paraventricular WMHs on executive function (Mediation effect: -0.117; 95%CI: -4.042,-0.011; p < 0.05). Among the WMHs subjects without cognitive impairment, the increased NVC of the left basal ganglia significantly correlated with the MoCA score (r = 0.539, p < 0.05).
Conclusion: These findings reveal an underlying neurovascular mechanism of WMHs-related cognitive impairment. The neurovascular functions of the left amygdala and left basal ganglia may involve cognitive damage and compensation, respectively, and can be used as potential biomarkers and therapeutic targets for cognitive impairment in patients with WMHs.
期刊介绍：
Neuroradiology aims to provide state-of-the-art medical and scientific information in the fields of Neuroradiology, Neurosciences, Neurology, Psychiatry, Neurosurgery, and related medical specialities. Neuroradiology as the official Journal of the European Society of Neuroradiology receives submissions from all parts of the world and publishes peer-reviewed original research, comprehensive reviews, educational papers, opinion papers, and short reports on exceptional clinical observations and new technical developments in the field of Neuroimaging and Neurointervention. The journal has subsections for Diagnostic and Interventional Neuroradiology, Advanced Neuroimaging, Paediatric Neuroradiology, Head-Neck-ENT Radiology, Spine Neuroradiology, and for submissions from Japan. Neuroradiology aims to provide new knowledge about and insights into the function and pathology of the human nervous system that may help to better diagnose and treat nervous system diseases. Neuroradiology is a member of the Committee on Publication Ethics (COPE) and follows the COPE core practices. Neuroradiology prefers articles that are free of bias, self-critical regarding limitations, transparent and clear in describing study participants, methods, and statistics, and short in presenting results. Before peer-review all submissions are automatically checked by iThenticate to assess for potential overlap in prior publication.
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