{"title":"Ferlapioside: a new bromine substituted iridoid glycoside from the roots of <i>Ferula lapidosa</i> Korovin.","authors":"Xin-Xin Li, Kholida Ibodullaevna Khasanova, Jia-Huan Shang, Anarbay Uraimovich Babekov, Wen-Jun Li, Jing-Juan Li, Hong-Tao Zhu, Komila Alibekovna Eshbakova, Ying-Jun Zhang","doi":"10.1080/14786419.2024.2432613","DOIUrl":null,"url":null,"abstract":"<p><p>One new bromine substituted iridoid glycoside, ferlapioside (<b>1</b>), was isolated from the roots of <i>Ferula lapidosa</i> Korovin, together with 10 known ones including seven iridoid glycosides (<b>2</b>-<b>8</b>) and three sesquiterpene lactones (<b>9</b>-<b>11</b>). Their structures were elucidated by extensive spectroscopic analyses, e.g. 1D and 2D-NMR, HR-ESI-MS, IR, UV, CD techniques, and comparison with literature values. Compounds <b>1</b> and <b>3</b>-<b>11</b> were evaluated for inhibitory activity against LPS-induced NO production in the RAW 264.7 cells and the <i>in vitro</i> cytotoxic activity against five human cancer cell lines (HL-60, A549, SMMC-7721, MDA-MB-231 and SW480). However, none of them exhibit significant anti-inflammatory and cytotoxic activity. This study will provide a scientific basis and reference for the further development and utilisation of <i>Ferula</i> plants.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.9000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2024.2432613","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
One new bromine substituted iridoid glycoside, ferlapioside (1), was isolated from the roots of Ferula lapidosa Korovin, together with 10 known ones including seven iridoid glycosides (2-8) and three sesquiterpene lactones (9-11). Their structures were elucidated by extensive spectroscopic analyses, e.g. 1D and 2D-NMR, HR-ESI-MS, IR, UV, CD techniques, and comparison with literature values. Compounds 1 and 3-11 were evaluated for inhibitory activity against LPS-induced NO production in the RAW 264.7 cells and the in vitro cytotoxic activity against five human cancer cell lines (HL-60, A549, SMMC-7721, MDA-MB-231 and SW480). However, none of them exhibit significant anti-inflammatory and cytotoxic activity. This study will provide a scientific basis and reference for the further development and utilisation of Ferula plants.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
