Estimation of the phenolic content and in vivo evaluation of the anti-inflammatory and anti-ulcer activity of Rhus pentaphylla leaf and fruit extracts from Morocco.
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Abstract
The present study aimed to estimate the phenolic compounds and evaluate the anti-inflammatory and anti-ulcer activity of Rhus pentaphylla leaf and fruit extracts in rodents. Phytochemical identification of the extracts was performed using HPLC technique. The anti-inflammatory property of the extracts was studied using three animal models of inflammation: xylene-induced ear swelling in Swiss albino mice, paw edoema and carrageenan-induced air pocketing in Sprague Dawley rats. The antiulcer activity of the extracts was evaluated through HCl/ethanol-induced acute gastric lesions in rats. HPLC results revealed the presence of epicatechin, caffeic acid and rutin in the leaf extract, while quercetin and kaempferol were identified in the fruit extract. Both leaf and fruit extracts demonstrated significant anti-inflammatory potential. Additionally, the extracts inhibited leukocyte migration and exhibited a strong gastroprotective effect. These remarkable in vivo pharmacological activities of Rhus pentaphylla extracts, linked to their bioactive compounds, demonstrate their potential for possible therapeutic applications.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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