Anti-metastatic extracellular vesicles carrying DNA

IF 23.5 1区医学 Q1 ONCOLOGY

Nature cancer Pub Date : 2024-12-03 DOI:10.1038/s43018-024-00829-7

Janusz Rak

引用次数: 0

Abstract

Cancer cells often secrete extracellular vesicles (EVs), bubble-like structures thought to elicit pro-metastatic states. New work shows that colorectal cancers systemically export their genetic material attached to the surface of specific EVs. These DNA-carrying EVs are taken up by macrophages in the liver, activating anti-metastatic immune responses.

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携带DNA的抗转移细胞外囊泡。

癌细胞经常分泌细胞外囊泡（EVs），这种泡状结构被认为会引发促转移状态。新的研究表明，结直肠癌系统地输出其附着在特定ev表面的遗传物质。这些携带dna的ev被肝脏中的巨噬细胞吸收，激活抗转移性免疫反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature cancer Medicine-Oncology

CiteScore

31.10

自引率

1.80%

发文量

129

期刊介绍： Cancer is a devastating disease responsible for millions of deaths worldwide. However, many of these deaths could be prevented with improved prevention and treatment strategies. To achieve this, it is crucial to focus on accurate diagnosis, effective treatment methods, and understanding the socioeconomic factors that influence cancer rates. Nature Cancer aims to serve as a unique platform for sharing the latest advancements in cancer research across various scientific fields, encompassing life sciences, physical sciences, applied sciences, and social sciences. The journal is particularly interested in fundamental research that enhances our understanding of tumor development and progression, as well as research that translates this knowledge into clinical applications through innovative diagnostic and therapeutic approaches. Additionally, Nature Cancer welcomes clinical studies that inform cancer diagnosis, treatment, and prevention, along with contributions exploring the societal impact of cancer on a global scale. In addition to publishing original research, Nature Cancer will feature Comments, Reviews, News & Views, Features, and Correspondence that hold significant value for the diverse field of cancer research.