Association of the atherogenic index of plasma and modified triglyceride-glucose indices with digestive diseases among middle-aged and older population in China.
Tiantian Gao, Mudan Ren, Yun Feng, Yarui Li, Xv Zhang, Shuixiang He
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引用次数: 0
Abstract
Background: Previous studies have shown that metabolic imbalances contribute to digestive diseases. This study aimed to investigate the relationship of the atherogenic index of plasma (AIP) and modified triglyceride-glucose (TyG) indices with digestive diseases.
Methods: We recruited participants aged 45 years or older from the China Health and Retirement Longitudinal Study (CHARLS, 2011 - 2020). The indices assessed included AIP, TyG, triacylglycerol glucose-waist circumference (TyG-WC), the triacylglycerol glucose-waist-to-height ratio (TyG-WHtR), and the triacylglycerol glucose-body mass index (TyG-BMI). We used logistic regression and restricted cubic spline (RCS) analyses to examine the associations between these indices and the incidence of digestive diseases.
Results: A total of 4,453 participants were included in our analysis, 53.3% of whom were female, with an average age of 60 years. The incidence of digestive diseases in middle-aged and older adults was 6.18%. Compared with those in the lowest tertile group, the odds ratios (ORs) with 95% confidence intervals (CIs) for digestive diseases in the highest tertile for AIP, TyG, TyG-WC, TyG-WHtR, and TyG-BMI were 1.452 (1.07-1.972), 1.193 (0.873-1.631), 1.349 (1.044-1.743), 1.5 (1.089-2.068), and 1.312 (0.956-1.799), respectively. Sensitivity analyses confirmed the robustness of the correlations between these indices and digestive diseases.
Conclusion: Our study revealed that the AIP, TyG-WC, and TyG-WHtR were independently associated with the incidence of digestive diseases. These findings highlight the importance of considering and optimizing metabolic factors in management strategies for digestive diseases.
期刊介绍：
Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds.
Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.
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